n− 3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

SR Shaikh, CA Jolly, RS Chapkin - Molecular aspects of medicine, 2012 - Elsevier
Fish oil, enriched in bioactive n− 3 polyunsaturated fatty acids (PUFA), has therapeutic value
for the treatment of inflammation-associated disorders. The effects of n− 3 PUFAs are …

Regulatory activity of polyunsaturated fatty acids in T-cell signaling

W Kim, NA Khan, DN McMurray, IA Prior, N Wang… - Progress in lipid …, 2010 - Elsevier
n− 3 Polyunsaturated fatty acids (PUFA) are considered to be authentic immunosuppressors
and appear to exert beneficial effects with respect to certain immune-mediated diseases. In …

Immunomodulation by polyunsaturated fatty acids: mechanisms and effects

TM Stulnig - International archives of allergy and immunology, 2003 - karger.com
Polyunsaturated fatty acids (PUFAs) modulate immune responses, thereby exerting
beneficial effects in a variety of inflammatory disorders. PUFAs of the n-3 series that are …

N-3 polyunsaturated fatty acids modulate B cell activity in pre-clinical models: Implications for the immune response to infections

J Whelan, KM Gowdy, SR Shaikh - European journal of pharmacology, 2016 - Elsevier
B cell antigen presentation, cytokine production, and antibody production are targets of
pharmacological intervention in inflammatory and infectious diseases. Here we review …

Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection

SR Shaikh, M Edidin - Chemistry and Physics of Lipids, 2008 - Elsevier
Polyunsaturated fatty acids (PUFAs), notably of the n-3 series, have immunosuppressive
effects which make these molecules candidates for treating inflammatory symptoms …

Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-κB activation

M Zeyda, MD Säemann, KM Stuhlmeier… - Journal of Biological …, 2005 - ASBMB
Polyunsaturated fatty acids (PUFAs) modulate immune responses leading to clinically
significant beneficial effects in a variety of inflammatory disorders. PUFA effects on T cells …

n− 3 Fatty acids uniquely affect anti-microbial resistance and immune cell plasma membrane organization

DN McMurray, DL Bonilla, RS Chapkin - Chemistry and physics of lipids, 2011 - Elsevier
It is now well established that dietary lipids are incorporated into macrophage and T-cell
membrane microdomains, altering their structure and function. Within cell membranes, there …

Unsaturated fatty acids and their immunomodulatory properties

S Coniglio, M Shumskaya, E Vassiliou - Biology, 2023 - mdpi.com
Simple Summary Diet can influence human health in both positive and negative ways. Ω-3
polyunsaturated fatty acids have an overall positive effect on humans. The sources of these …

Dietary docosahexaenoic acid suppresses T cell protein kinase Cθ lipid raft recruitment and IL-2 production

YY Fan, LH Ly, R Barhoumi, DN McMurray… - The Journal of …, 2004 - journals.aai.org
To date, the proximal molecular targets through which dietary n-3 polyunsaturated fatty acids
(PUFA) suppress the inflammatory process have not been elucidated. Because cholesterol …

Omega-3 fatty acids, lipid rafts, and T cell signaling

TY Hou, DN McMurray, RS Chapkin - European journal of pharmacology, 2016 - Elsevier
Abstract n-3 polyunsaturated fatty acids (PUFA) have been shown in many clinical studies to
attenuate inflammatory responses. Although inflammatory responses are orchestrated by a …