Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly
damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder
characterized by loss of upper and lower motor neurons. Different mechanisms contribute to …

Strong evidence shows that mitochondrial dysfunction is involved in amyotrophic lateral
sclerosis (ALS), but despite the fact that mitochondria play a central role in excitotoxicity …

The amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized
by motoneurons death. Mutations in the superoxide dismutase 1 (SOD1) protein have been …

The etiology of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains to
be better understood. Based on the studies from ALS patients and transgenic animal …

A better understanding of the etiology of amyotrophic lateral sclerosis (ALS) is needed to
develop effective therapies for the treatment of this fatal neurodegenerative disease …

In amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a
vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease …

Mitochondria play a pivotal role in many metabolic and apoptotic pathways that regulate the
life and death of cells. Accumulating evidence suggests that mitochondrial dysfunction is …

Abstract Mutant Cu/Zn superoxide dismutase (SOD 1) causes mitochondrial alterations that
contribute to motor neuron demise in amyotrophic lateral sclerosis (ALS). When …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an adult onset
characterized by loss of both upper and lower motor neurons. In~ 10% of cases, patients …