Improved access to linear tetrameric hydroxamic acids with potential as radiochemical ligands for zirconium (IV)-89 PET imaging
CJM Brown, MP Gotsbacher… - Australian Journal of …, 2020 - CSIRO Publishing
Two new linear tetrameric hydroxamic acid ligands (3 and 4) have been prepared as
potential radioligands for immunological ZrIV-89 positron emission tomography (PET) …
potential radioligands for immunological ZrIV-89 positron emission tomography (PET) …
Investigation of Zr (IV) and 89 Zr (IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging
Single crystal X-ray diffraction shows that Zr (IV) forms an octa-coordinated complex with 4
bidentate hydroxamates whose solution structures were investigated by utilizing density …
bidentate hydroxamates whose solution structures were investigated by utilizing density …
Octadentate zirconium (IV)-loaded macrocycles with varied stoichiometry assembled from hydroxamic acid monomers using metal-templated synthesis
The reaction between Zr (IV) and the forward endo-hydroxamic acid monomer 4-[(5-
aminopentyl)(hydroxy) amino]-4-oxobutanoic acid (for-PBH) in a 1: 4 stoichiometry in the …
aminopentyl)(hydroxy) amino]-4-oxobutanoic acid (for-PBH) in a 1: 4 stoichiometry in the …
Development and in vitro evaluation of new bifunctional 89Zr-chelators based on the 6-amino-1, 4-diazepane scaffold for immuno-PET applications
B Klasen, D Lemcke, TL Mindt, G Gasser… - Nuclear Medicine and …, 2021 - Elsevier
Introduction Combination of hydroxamate bearing side chains with the 6-amino-1, 4-
diazepane scaffold provides a promising strategy for fast and stable 89 Zr-labeling of …
diazepane scaffold provides a promising strategy for fast and stable 89 Zr-labeling of …
Comment on “Investigation of Zr (iv) and 89 Zr (iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno …
A Bianchi, M Savastano - Chemical Communications, 2020 - pubs.rsc.org
An alternative analysis of the complexes formed by Zr (IV) with acetohydroxamate shows
that, in comparison with the results reported in the title article, a more complicated …
that, in comparison with the results reported in the title article, a more complicated …
Macrocycle‐Based Hydroxamate Ligands for Complexation and Immunoconjugation of 89Zirconium for Positron Emission Tomography (PET) Imaging
E Boros, JP Holland, N Kenton, N Rotile… - …, 2016 - Wiley Online Library
Four novel chelators (L1–L4) and their 89zirconium complexes were prepared and
compared with the 89zirconium desferrioxamine B (DFO) complex. The new chelates are …
compared with the 89zirconium desferrioxamine B (DFO) complex. The new chelates are …
Tripodal tris (hydroxypyridinone) ligands for immunoconjugate PET imaging with 89 Zr 4+: comparison with desferrioxamine-B
MT Ma, LK Meszaros, BM Paterson, DJ Berry… - Dalton …, 2015 - pubs.rsc.org
Due to its long half-life (78 h) and decay properties (77% electron capture, 23% β+, Emax=
897 keV, Eav= 397 keV, Eγ= 909 keV, Iγ= 100%) 89Zr is an appealing radionuclide for …
897 keV, Eav= 397 keV, Eγ= 909 keV, Iγ= 100%) 89Zr is an appealing radionuclide for …
Investigation of the complexation of nat Zr (IV) and 89 Zr (IV) by hydroxypyridinones for the development of chelators for PET imaging applications
Three hydroxypyridinone (HOPO) positional isomers–1, 2-HOPO (L1H) and its water soluble
analogue (L1′ H), 3, 2-HOPO (L2H) and 3, 4-HOPO (L3H) have been investigated for the …
analogue (L1′ H), 3, 2-HOPO (L2H) and 3, 4-HOPO (L3H) have been investigated for the …
Evaluation of the tetrakis (3-Hydroxy-4-Pyridinone) Ligand THPN with Zirconium (IV): thermodynamic solution studies, bifunctionalization, and in vivo assessment of …
C Buchwalder, MG Jaraquemada-Pelaez… - Inorganic …, 2019 - ACS Publications
Zirconium-89 (89Zr) is a suitable radionuclide for positron-emission tomography (PET) of
long-circulating targeting vectors such as monoclonal antibodies (mAbs). Due to stability …
long-circulating targeting vectors such as monoclonal antibodies (mAbs). Due to stability …
A new tetrapodal 3-hydroxy-4-pyridinone ligand for complexation of 89 zirconium for positron emission tomography (PET) imaging
C Buchwalder, C Rodríguez-Rodríguez… - Dalton …, 2017 - pubs.rsc.org
Zirconium-89 (89Zr) is an ideal radiometal isotope for antibody-based positron emission
tomography (immunoPET) as its physical half-life (3.27 days) is a good match with the …
tomography (immunoPET) as its physical half-life (3.27 days) is a good match with the …