BLyS family members govern selection and survival of cells in the pre-immune B cell
compartment, and emerging evidence suggests similar roles in antigen-experienced B cell …

These studies characterize BLyS responsiveness and receptor expression among
transitional and mature peripheral B cells. The results show a maturation-associated …

The BLyS family of receptors includes two cytokines, BLyS and APRIL; and three receptors,
BR3, BCMA and TACI. Together, these regulate the size and composition of peripheral B …

Understanding the homeostatic mechanisms governing lymphocyte pools achieves critical
importance as lymphocyte-targeted therapies expand in use and scope. The primacy of B …

B lymphocyte homeostasis encompasses the establishment and maintenance of
independently regulated niches, within which cells compete for viability promoting …

This study examines how B lymphocyte stimulator (BLyS) receptor expression and
responsiveness are influenced by B cell receptor (BcR) signaling. Our results show that …

The size and makeup of mature B cell compartments are controlled by the proportion of
immature B cells that complete differentiation, coupled with the average lifespan of mature B …

The BLyS family of ligands and receptors governs B cell homeostasis by controlling survival,
differentiation, and lifespan. This family consists of multiple receptors and ligands, allowing …

We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the
germinal center (GC) reaction and affinity maturation. Despite ample BLyS retention on B …

The mechanisms that maintain a pool of B cells that is adequately diverse yet devoid of
pathogenic autoreactivity remain poorly understood. B cells complete maturation after …