[HTML][HTML] Flavin monooxygenase-generated N-hydroxypipecolic acid is a critical element of plant systemic immunity

M Hartmann, T Zeier, F Bernsdorff, V Reichel-Deland… - Cell, 2018 - cell.com
Following a previous microbial inoculation, plants can induce broad-spectrum immunity to
pathogen infection, a phenomenon known as systemic acquired resistance (SAR). SAR …

N-hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis

YC Chen, EC Holmes, J Rajniak… - Proceedings of the …, 2018 - National Acad Sciences
Systemic acquired resistance (SAR) is a global response in plants induced at the site of
infection that leads to long-lasting and broad-spectrum disease resistance at distal …

The mobile SAR signal N-hydroxypipecolic acid induces NPR1-dependent transcriptional reprogramming and immune priming

I Yildiz, M Mantz, M Hartmann, T Zeier, J Kessel… - Plant …, 2021 - academic.oup.com
N-hydroxypipecolic acid (NHP) accumulates in the plant foliage in response to a localized
microbial attack and induces systemic acquired resistance (SAR) in distant leaf tissue …

The Arabidopsis flavin-dependent monooxygenase FMO1 is an essential component of biologically induced systemic acquired resistance

TE Mishina, J Zeier - Plant physiology, 2006 - academic.oup.com
Upon localized attack by necrotizing pathogens, plants gradually develop increased
resistance against subsequent infections at the whole-plant level, a phenomenon known as …

l‐lysine metabolism to N‐hydroxypipecolic acid: an integral immune‐activating pathway in plants

M Hartmann, J Zeier - The Plant Journal, 2018 - Wiley Online Library
Summary l‐lysine catabolic routes in plants include the saccharopine pathway to α‐
aminoadipate and decarboxylation of lysine to cadaverine. The current review will cover a …

Arabidopsis UGT76B1 glycosylates N-hydroxy-pipecolic acid and inactivates systemic acquired resistance in tomato

EC Holmes, YC Chen, MB Mudgett, ES Sattely - The Plant Cell, 2021 - academic.oup.com
Systemic acquired resistance (SAR) is a mechanism that plants utilize to connect a local
pathogen infection to global defense responses. N-hydroxy-pipecolic acid (NHP) and a …

Pipecolic acid orchestrates plant systemic acquired resistance and defense priming via salicylic acid-dependent and-independent pathways

F Bernsdorff, AC Döring, K Gruner, S Schuck… - The Plant …, 2016 - academic.oup.com
We investigated the relationships of the two immune-regulatory plant metabolites, salicylic
acid (SA) and pipecolic acid (Pip), in the establishment of plant systemic acquired resistance …

A role for a flavin‐containing mono‐oxygenase in resistance against microbial pathogens in Arabidopsis

M Koch, S Vorwerk, C Masur, G Sharifi‐Sirchi… - The Plant …, 2006 - Wiley Online Library
Using activation tagging in the Arabidopsis Col‐0 rps2‐101C background, we identified a
mutant (FMO1‐3D) that showed virtually no symptoms after inoculation with virulent …

N-hydroxypipecolic acid and salicylic acid: a metabolic duo for systemic acquired resistance

M Hartmann, J Zeier - Current opinion in plant biology, 2019 - Elsevier
Recent research has established that the pipecolate pathway, a three-step biochemical
sequence from l-lysine to N-hydroxypipecolic acid (NHP), is central for plant systemic …

[HTML][HTML] Signals of systemic immunity in plants: progress and open questions

AL Ádám, ZÁ Nagy, G Kátay, E Mergenthaler… - International journal of …, 2018 - mdpi.com
Systemic acquired resistance (SAR) is a defence mechanism that induces protection against
a wide range of pathogens in distant, pathogen-free parts of plants after a primary …