[HTML][HTML] Kidney organoids and tubuloids

FA Yousef Yengej, J Jansen, MB Rookmaaker… - Cells, 2020 - mdpi.com
In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem
or progenitor cell (ASC)-based kidney tubuloids have emerged as advanced in vitro models …

Human kidney organoids: progress and remaining challenges

R Nishinakamura - Nature Reviews Nephrology, 2019 - nature.com
Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

[HTML][HTML] Human pluripotent stem cell-derived kidney organoids with improved collecting duct maturation and injury modeling

K Uchimura, H Wu, Y Yoshimura, BD Humphreys - Cell reports, 2020 - cell.com
Maximizing the potential of human kidney organoids for drug testing and regenerative
medicine and to model development and disease requires addressing cell immaturity, the …

Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids

FA Yousef Yengej, J Jansen… - Proceedings of the …, 2023 - National Acad Sciences
Kidney organoids generated from induced pluripotent stem cells (iPSC) have proven
valuable for studies of kidney development, disease, and therapeutic screening. However …

[HTML][HTML] Overcoming kidney organoid challenges for regenerative medicine

T Geuens, CA van Blitterswijk… - NPJ Regenerative …, 2020 - nature.com
Kidney organoids derived from human induced pluripotent stem cells bear the potential to
be used as a regenerative medicine renal replacement therapy. Advances in developmental …

Kidney organoids: a pioneering model for kidney diseases

M Tekguc, RC Van Gaal, SGM Uzel, N Gupta… - Translational …, 2022 - Elsevier
The kidney is a vital organ that regulates the bodily fluid and electrolyte homeostasis via
tailored urinary excretion. Kidney injuries that cause severe or progressive chronic kidney …

[HTML][HTML] Stem cell-derived kidney organoids: engineering the vasculature

M Koning, CW van den Berg, TJ Rabelink - Cellular and Molecular Life …, 2020 - Springer
Kidney organoids can be generated from human pluripotent stem cells (PSCs) using
protocols that resemble the embryonic development of the kidney. The renal structures thus …

[HTML][HTML] Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network

JH Low, P Li, EGY Chew, B Zhou, K Suzuki, T Zhang… - Cell stem cell, 2019 - cell.com
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …

Kidney organoids: accurate models or fortunate accidents

MH Little, AN Combes - Genes & Development, 2019 - genesdev.cshlp.org
There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

[HTML][HTML] The “3Ds” of growing kidney organoids: Advances in nephron development, disease modeling, and drug screening

BE Chambers, NE Weaver, RA Wingert - Cells, 2023 - mdpi.com
A kidney organoid is a three-dimensional (3D) cellular aggregate grown from stem cells in
vitro that undergoes self-organization, recapitulating aspects of normal renal development to …