Sustained neuronal activity demands a rapid resupply of synaptic vesicles to maintain
reliable synaptic transmission. Such vesicle replenishment is accelerated by submicromolar …

It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …

Neurotransmission requires a balance of synaptic vesicle exocytosis and endocytosis.
Synaptotagmin I (Syt I) is widely regarded as the primary calcium sensor for synaptic vesicle …

SYNAPTOTAGMINS (Syts) are brain-specific Ca2+/phospholipidbinding proteins1–5. In
hippocampal synapses, Syt I is essential for fast Ca2+-dependent synaptic vesicle …

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles
and released by exocytosis upon activation. The vesicle membrane is then retrieved by …

At most synapses in the brain, short-term plasticity dynamically modulates synaptic strength.
Rapid frequency-dependent changes in synaptic strength have key roles in sensory …

Synaptotagmin I (syt1) is required for normal rates of synaptic vesicle endo-and exocytosis.
However, whether the kinetic defects observed during endocytosis in Syt1 knockout neurons …

Spontaneous' mini'release occurs at all synapses, but its nature remains enigmatic. We
found that> 95% of spontaneous release in murine cortical neurons was induced by Ca2+ …

Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent
long-term potentiation (LTP) shapes neural circuits and mediates learning and memory …

Exocytosis at synapses involves fusion between vesicles and the plasma membrane.
Although compound fusion between vesicles, was proposed to occur at ribbon-type …