The proximate mechanisms by which physical activity (PA) slows senescence and
decreases morbidity and mortality have been extensively documented. However, we lack an …

Observational studies report a strong inverse relationship between leisure-time physical
activity and all-cause mortality. Despite suggestive evidence from population-based …

Human evolution suggests that the default position for health is to be physically active.
Inactivity, by contrast, has serious negative effects on health across the lifespan. Therefore …

More and more people are living into the 90s or becoming centenarians. But, the gift of
increased 'age span'seldom equates with an improved 'health-span'. Governments across …

Several metabolic alterations accumulate over time along with a reduction in biological
fitness, suggesting the existence of a" metabolic clock" that controls aging. Multiple inborn …

Background and objectives: The thrifty phenotype hypothesis proposes that late-life
metabolic diseases result from mismatch between early-life and adulthood nutrition. More …

Recent advances in medicine and life-expectancy gains have fueled multidisciplinary
research into the limits of human lifespan [1–3]. Ultimately, how long humans can live for …

Human life history contains a series of paradoxes not easily explained by classical life
history theory. Although overall reproductive output is higher than in related primates …

Lifetime physical inactivity interacts with secondary aging (ie, aging caused by diseases and
environmental factors) in three patterns of response. First, lifetime physical inactivity confers …

Noteworthy data is emerging to support the existence of longevity-enabling genes. Our
observations of the relationship between reproductive fitness and longevity among …