[HTML][HTML] The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense
JL Horton, MT Davidson, C Kurishima, RB Vega… - JCI insight, 2019 - ncbi.nlm.nih.gov
Evidence has emerged that the failing heart increases utilization of ketone bodies. We
sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing …
sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing …
The failing heart relies on ketone bodies as a fuel
Background—Significant evidence indicates that the failing heart is energy starved. During
the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel …
the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel …
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency
KL Ho, L Zhang, C Wagg, R Al Batran… - Cardiovascular …, 2019 - academic.oup.com
Aims The failing heart is energy-starved and inefficient due to perturbations in energy
metabolism. Although ketone oxidation has been shown recently to increase in the failing …
metabolism. Although ketone oxidation has been shown recently to increase in the failing …
Ketone ester treatment improves cardiac function and reduces pathologic remodeling in preclinical models of heart failure
Background: Accumulating evidence suggests that the failing heart reprograms fuel
metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone …
metabolism toward increased utilization of ketone bodies and that increasing cardiac ketone …
Ketones step to the plate: a game changer for metabolic remodeling in heart failure?
690 Circulation February 23, 2016 failing heart. Because ketone availability is a primary
determinant of ketone utilization, these observations suggest that impaired systemic …
determinant of ketone utilization, these observations suggest that impaired systemic …
Myocardial ketones metabolism in heart failure
Ketone bodies can become a major source of adenosine triphosphate production during
stress to maintain bioenergetic homeostasis in the brain, heart, and skeletal muscles. In the …
stress to maintain bioenergetic homeostasis in the brain, heart, and skeletal muscles. In the …
Ketones and the heart: metabolic principles and therapeutic implications
The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …
Ketones can become the major fuel source for the heart but do not increase cardiac efficiency
Aims Ketones have been proposed to be a 'thrifty'fuel for the heart and increasing cardiac
ketone oxidation can be cardioprotective. However, it is unclear how much ketone oxidation …
ketone oxidation can be cardioprotective. However, it is unclear how much ketone oxidation …
Ketone bodies for the failing heart: fuels that can fix the engine?
Accumulating evidence suggests that the failing heart reverts energy metabolism toward
increased utilization of ketone bodies. Despite many discrepancies in the literature …
increased utilization of ketone bodies. Despite many discrepancies in the literature …
[HTML][HTML] Cardiomyocyte-specific deficiency of ketone body metabolism promotes accelerated pathological remodeling
RC Schugar, AR Moll, DA d'Avignon… - Molecular …, 2014 - Elsevier
Objective Exploitation of protective metabolic pathways within injured myocardium still
remains an unclarified therapeutic target in heart disease. Moreover, while the roles of …
remains an unclarified therapeutic target in heart disease. Moreover, while the roles of …