The disposition of tanzisertib [(1S, 4R)-4-(9-((S) tetrahydrofuran-3-yl)-8-(2, 4, 6-
trifluorophenyla-mino)-9H-purin-2-ylamino) cyclohexanol], a potent, orally active c-Jun …

The disposition of tanzisertib [(1S, 4R)-4-(9-((S) tetrahydrofuran-3-yl)-8-(2, 4, 6-
trifluorophenylamino)-9H-purin-2-ylamino) cyclohexanol], a potent, orally active c-Jun amino …

In vitro metabolism of Tanzisertib [(1S, 4R)-4-(9-((S) tetrahydrofuran-3-yl)-8-(2, 4, 6-
trifluorophe-nylamino)-9H-purin-2-ylamino) cyclohexanol], a potent, selective c-Jun amino …

As a result of emerging biological data suggesting that within the c-Jun N-terminal kinase
(JNK) family, JNK1 and not JNK2 or JNK3 may be primarily responsible for fibrosis …

US6277989B1 - Quinazoline derivatives as medicaments - Google Patents US6277989B1 -
Quinazoline derivatives as medicaments - Google Patents Quinazoline derivatives as …

US6903096B2 - Quinazoline derivatives as medicaments - Google Patents US6903096B2 -
Quinazoline derivatives as medicaments - Google Patents Quinazoline derivatives as …

The novel pyrimidinyl pyrazole derivative, 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-[4-(3-
chlorophenyl)-1-piperazinyl]-1-trans-propene hydrochloride (DZ-3358), was found through …

Indiscriminately suppressing total c-Jun N-terminal kinase (JNK) activity is not an
appropriate strategy because each JNK appears to have a distinct function in cancer …

BACKGROUND A large number of cytokines participate in the inflamma tory response,
including IL-1, IL6, IL-8 and TNF-C. Over production of cytokines such as IL-1 and TNF-C …

Abstract RS-1541 is a 13-O-palmitoyl derivative of rhizoxin, an inhibitor of tubulin
polymerization. After intravenous administration of RS-1541 to mice bearing M5076 …