Enzymes of glutathione metabolism, particularly gamma-glutamyltransferase (GGT) and
glutathione S-transferase (GST), play a role in multistage hepatocarcinogenesis. The …

Much has been learned about the function of glutathione (GSH) and other thiols as
antioxidants, radioprotectors and radical scavengers. Recent reports point out that GSH and …

Previous studies from our laboratories have shown that catabotism of glutathione (GSH) by γ-
glutamyl transpeptidase (GGT) in the presence of transition metals leads to oxidative …

A histochemical procedure was used to determine the presence of γ-glutamyl
transpeptidase (GGT) in the livers of control, regenerating and carcinogen-treated mice …

Glutathione (GSH)-driven lipid peroxidation (LPO) in vitro was catalyzed by γ-
glutamyltranspeptidase (GGT; EC 2.3. 2.2.). The reaction required iron, iron chelators and …

Our laboratory has developed an in vivo short-term screening test for hepatocarcinogens
based on quantitation of γ-glutamyl transpeptidase (γ-GT) positive foci. However, γ-GT …

Rat chemical hepatocarcinogenesis has been most extensively studied and sequential
analysis of the processes involved has played an important role in generating the …

The expression of gamma-glutamyl transpeptidase (GGT) is essential to maintaining
cysteine levels in the body. GGT is a cell surface enzyme that hydrolyzes the gamma …

Using immunohistochemical demonstration of glutathione S-transferase placental type (GST-
P) and histochemical demonstration of γ-glutamyltransferase (γ-GT), the long-term …

A number of studies indicate that cell proliferation can be modulated by changes in the
redox balance of (soluble and protein) cellular thiols. Free radical processes, including lipid …