Nanoconnectomic upper bound on the variability of synaptic plasticity

TM Bartol Jr, C Bromer, J Kinney, MA Chirillo… - Elife, 2015 - elifesciences.org
Information in a computer is quantified by the number of bits that can be stored and
recovered. An important question about the brain is how much information can be stored at a …

Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits

RP Costa, PJ Sjöström… - Frontiers in computational …, 2013 - frontiersin.org
Short-term synaptic plasticity is highly diverse across brain area, cortical layer, cell type, and
developmental stage. Since short-term plasticity (STP) strongly shapes neural dynamics, this …

Network self-organization explains the statistics and dynamics of synaptic connection strengths in cortex

P Zheng, C Dimitrakakis, J Triesch - PLoS computational biology, 2013 - journals.plos.org
The information processing abilities of neural circuits arise from their synaptic connection
patterns. Understanding the laws governing these connectivity patterns is essential for …

Memory capacities for synaptic and structural plasticity

A Knoblauch, G Palm, FT Sommer - Neural Computation, 2010 - ieeexplore.ieee.org
Neural associative networks with plastic synapses have been proposed as computational
models of brain functions and also for applications such as pattern recognition and …

High-degree neurons feed cortical computations

NM Timme, S Ito, M Myroshnychenko… - PLoS computational …, 2016 - journals.plos.org
Recent work has shown that functional connectivity among cortical neurons is highly varied,
with a small percentage of neurons having many more connections than others. Also, recent …

The information efficacy of a synapse

M London, A Schreibman, M Häusser, ME Larkum… - Nature …, 2002 - nature.com
We provide a functional measure, the synaptic information efficacy (SIE), to assess the
impact of synaptic input on spike output. SIE is the mutual information shared by the …

Multiplicative dynamics underlie the emergence of the log-normal distribution of spine sizes in the neocortex in vivo

Y Loewenstein, A Kuras, S Rumpel - Journal of Neuroscience, 2011 - Soc Neuroscience
What fundamental properties of synaptic connectivity in the neocortex stem from the ongoing
dynamics of synaptic changes? In this study, we seek to find the rules shaping the stationary …

Is a 4-bit synaptic weight resolution enough?–constraints on enabling spike-timing dependent plasticity in neuromorphic hardware

T Pfeil, TC Potjans, S Schrader, W Potjans… - Frontiers in …, 2012 - frontiersin.org
Large-scale neuromorphic hardware systems typically bear the trade-off between detail
level and required chip resources. Especially when implementing spike-timing dependent …

Synaptic size dynamics as an effectively stochastic process

A Statman, M Kaufman, A Minerbi, NE Ziv… - PLoS computational …, 2014 - journals.plos.org
Long-term, repeated measurements of individual synaptic properties have revealed that
synapses can undergo significant directed and spontaneous changes over time scales of …

Rich-club organization in effective connectivity among cortical neurons

S Nigam, M Shimono, S Ito, FC Yeh… - Journal of …, 2016 - Soc Neuroscience
The performance of complex networks, like the brain, depends on how effectively their
elements communicate. Despite the importance of communication, it is virtually unknown …