White matter deterioration is associated with cognitive impairment in healthy aging and
Alzheimer's disease. It is critical to identify interventions that can slow down white matter …

Aging is associated with decline in white matter (WM) microstructure, decreased cognitive
functioning, and increased risk of Alzheimer's disease and related dementias. Recent …

White matter structure declines with advancing age and has been associated with a decline
in memory and executive processes in older adulthood. Yet, recent research suggests that …

Background White matter (WM) integrity declines with normal aging. Physical activity may
attenuate age-related WM integrity changes and improve cognitive function. This study …

Age-related differences in white matter (WM) integrity are substantial, but it is unknown
whether between-subject variability in WM integrity influences the capacity for cognitive …

Cerebral white matter (WM) degeneration occurs with increasing age and is associated with
declining cognitive function. Research has shown that cardiorespiratory fitness and exercise …

A growing body of research indicates benefits of cognitive training in older adults, but the
neuronal mechanisms underlying the effect of cognitive intervention remains largely …

Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive
function in late life, but the neural correlates for these relationships are unclear. To study …

Importance Pathophysiologic mechanisms leading to loss of white matter integrity and the
temporal positioning of biomarkers of white matter integrity relative to the biomarkers of gray …

The few extant reports of longitudinal white matter (WM) changes in healthy aging, using
diffusion tensor imaging (DTI), reveal substantial differences in change across brain regions …