Cerebellar climbing fibers multiplex movement and reward signals during a voluntary movement task in mice
K Ikezoe, N Hidaka, S Manita, M Murakami… - Communications …, 2023 - nature.com
Cerebellar climbing fibers convey sensorimotor information and their errors, which are used
for motor control and learning. Furthermore, they represent reward-related information …
for motor control and learning. Furthermore, they represent reward-related information …
Dynamic organization of cerebellar climbing fiber response and synchrony in multiple functional components reduces dimensions for reinforcement learning
Cerebellar climbing fibers convey diverse signals, but how they are organized in the
compartmental structure of the cerebellar cortex during learning remains largely unclear. We …
compartmental structure of the cerebellar cortex during learning remains largely unclear. We …
Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells
There is increasing evidence for a cerebellar contribution to cognitive processing, but the
specific input pathways conveying this information remain unclear. We probed the role of …
specific input pathways conveying this information remain unclear. We probed the role of …
Modular organization of cerebellar climbing fiber inputs during goal-directed behavior
S Tsutsumi, N Hidaka, Y Isomura, M Matsuzaki… - Elife, 2019 - elifesciences.org
The cerebellum has a parasagittal modular architecture characterized by precisely
organized climbing fiber (CF) projections that are congruent with alternating aldolase …
organized climbing fiber (CF) projections that are congruent with alternating aldolase …
Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions
The prevailing model of cerebellar learning states that climbing fibers (CFs) are both driven
by, and serve to correct, erroneous motor output. However, this model is grounded largely in …
by, and serve to correct, erroneous motor output. However, this model is grounded largely in …
Climbing fibers provide graded error signals in cerebellar learning
Y Zang, E De Schutter - Frontiers in Systems Neuroscience, 2019 - frontiersin.org
The cerebellum plays a critical role in coordinating and learning complex movements.
Although its importance has been well recognized, the mechanisms of learning remain hotly …
Although its importance has been well recognized, the mechanisms of learning remain hotly …
Cerebellar climbing fibers encode expected reward size
Climbing fiber inputs to the cerebellum encode error signals that instruct learning. Recently,
evidence has accumulated to suggest that the cerebellum is also involved in the processing …
evidence has accumulated to suggest that the cerebellum is also involved in the processing …
Sensory-driven enhancement of calcium signals in individual Purkinje cell dendrites of awake mice
Climbing fibers (CFs) are thought to contribute to cerebellar plasticity and learning by
triggering a large influx of dendritic calcium in the postsynaptic Purkinje cell (PC) to signal …
triggering a large influx of dendritic calcium in the postsynaptic Purkinje cell (PC) to signal …
Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum
Classical models of cerebellar learning posit that climbing fibers operate according to a
supervised learning rule to instruct changes in motor output by signaling the occurrence of …
supervised learning rule to instruct changes in motor output by signaling the occurrence of …
Transmission of predictable sensory signals to the cerebellum via climbing fiber pathways is gated during exploratory behavior
CL Lawrenson, TC Watson, R Apps - Journal of Neuroscience, 2016 - Soc Neuroscience
Pathways arising from the periphery that target the inferior olive [spino-olivocerebellar
pathways (SOCPs)] are a vital source of information to the cerebellum and are modulated …
pathways (SOCPs)] are a vital source of information to the cerebellum and are modulated …