Over the last two decades, fluorine substitution has become one of the essential structural
traits in modern pharmaceuticals. Thus, about half of the most successful drugs (blockbuster …

The objective of this review is to provide an update on the fluorine-containing drugs
approved by US Food and Drug Administration in the span of past five years (2018–2022) …

The inclusion of fluorine atoms or heterocyclic moiety into drug structures represents a
recurrent motif in medicinal chemistry. The combination of these two features is constantly …

Eleven new fluorine-containing FDA-approved drugs have been profiled and details of their
discovery and preparation are discussed. Therapeutic areas include schizophrenia …

Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …

Thirteen new fluorine-containing drugs, which have been granted approval by the US Food
and Drug Administration (FDA) in 2020, are profiled in this review. Therapeutic areas of …

Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …

Fluorine-containing small molecules have occupied an especial position in drug discovery
research. The successful clinical use of fluorinated corticosteroids in the 1950s and …

The role of organo-fluorine compounds in modern health, food and energy related industries
is widely-appreciated. The unique properties that fluorine imparts to organic molecules …

During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …