Red blood cell metabolism in vivo and in vitro

A D'Alessandro, AT Anastasiadi, VL Tzounakas… - Metabolites, 2023 - mdpi.com
Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond …

T Nemkov, JA Reisz, Y Xia, JC Zimring… - Expert review of …, 2018 - Taylor & Francis
Introduction: Recently, the classification of two 'novel'organs, the mesentere and interstitium,
was saluted as a scientific breakthrough and disseminated into mainstream media. The …

[HTML][HTML] Red blood cell proteomics update: is there more to discover?

A D'Alessandro, M Dzieciatkowska, T Nemkov… - Blood …, 2017 - ncbi.nlm.nih.gov
A great deal of interest has been attracted by backof-the-envelope calculations suggesting
that bacterial cells (recently revised to be~ 3.9× 1013) outnumber the total number of host …

[HTML][HTML] Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate …

A D'Alessandro, X Fu, T Kanias, JA Reisz… - …, 2021 - ncbi.nlm.nih.gov
Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …

Red blood cell metabolism under prolonged anaerobic storage

A D'Alessandro, F Gevi, L Zolla - Molecular BioSystems, 2013 - pubs.rsc.org
Oxygen dependent modulation of red blood cell metabolism is a long investigated issue.
However, the recent introduction of novel mass spectrometry-based approaches lends itself …

Metabolomics in transfusion medicine

T Nemkov, KC Hansen, LJ Dumont… - Transfusion, 2016 - Wiley Online Library
Biochemical investigations on the regulatory mechanisms of red blood cell (RBC) and
platelet (PLT) metabolism have fostered a century of advances in the field of transfusion …

Citrate metabolism in red blood cells stored in additive solution‐3

A D'Alessandro, T Nemkov, T Yoshida, A Bordbar… - …, 2017 - Wiley Online Library
BACKGROUND Red blood cells (RBCs) are thought to have a relatively simple metabolic
network compared to other human cell types. Recent proteomics reports challenge the …

Red blood cells are dynamic reservoirs of cytokines

E Karsten, E Breen, BR Herbert - Scientific reports, 2018 - nature.com
Red blood cells (RBCs) have been shown to affect immune function and can induce
inflammatory responses after transfusion. The transfusion of washed RBCs can significantly …

Survival of red blood cells after transfusion: processes and consequences

GJ Bosman - Frontiers in physiology, 2013 - frontiersin.org
The currently available data suggest that efforts toward improving the quality of red blood
cell (RBC) blood bank products should concentrate on:(1) preventing the removal of a …

Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III …

A D'Alessandro, R Culp‐Hill, JA Reisz… - …, 2019 - Wiley Online Library
BACKGROUND Biological and technical variability has been increasingly appreciated as a
key factor impacting red blood cell (RBC) storability and, potentially, transfusion outcomes …