The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles
B Trautz, H Wiedemann, C Lüchtenborg… - Journal of Biological …, 2017 - ASBMB
The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1
(HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the …
(HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the …
An N-glycosylated form of SERINC5 is specifically incorporated into HIV-1 virions
S Sharma, MK Lewinski, J Guatelli - Journal of virology, 2018 - Am Soc Microbiol
ABSTRACT SERINC5 is an inhibitor of retroviral infectivity that is counteracted by viral
proteins, including HIV-1 Nef. Inhibition of infectivity by SERINC5 is associated with its …
proteins, including HIV-1 Nef. Inhibition of infectivity by SERINC5 is associated with its …
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry
The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …
The antagonism of HIV-1 Nef to SERINC5 particle infectivity restriction involves the counteraction of virion-associated pools of the restriction factor
B Trautz, V Pierini, R Wombacher, B Stolp… - Journal of …, 2016 - Am Soc Microbiol
ABSTRACT SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell
inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor …
inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor …
A conserved acidic-cluster motif in SERINC5 confers partial resistance to antagonism by HIV-1 Nef
CA Stoneham, PW Ramirez, R Singh, M Suarez… - Journal of …, 2020 - Am Soc Microbiol
The cellular protein SERINC5 inhibits the infectivity of diverse retroviruses, and its activity is
counteracted by the glycosylated Gag (glycoGag) protein of murine leukemia virus (MLV) …
counteracted by the glycosylated Gag (glycoGag) protein of murine leukemia virus (MLV) …
SERINC5 inhibits HIV-1 infectivity by altering the conformation of gp120 on HIV-1 particles
A Featherstone, C Aiken - Journal of Virology, 2020 - Am Soc Microbiol
ABSTRACT SERINC5 is a 10-transmembrane-domain cellular protein that is incorporated
into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV …
into budding HIV-1 particles and reduces HIV-1 infectivity by inhibiting virus-cell fusion. HIV …
Effect of HIV-1 Env on SERINC5 antagonism
ABSTRACT SERINC5 is able to restrict HIV-1 infection by drastically impairing the infectivity
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
[HTML][HTML] Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5
Abstract SERINC5 (S5) is a multi-span transmembrane protein that potently blocks the
infectivity of HIV-1 produced by human T-cells. The ability of S5 to restrict infectivity …
infectivity of HIV-1 produced by human T-cells. The ability of S5 to restrict infectivity …
SERINC5 mediates a postintegration block to HIV-1 gene expression in macrophages
ABSTRACT HIV-1 antagonizes SERINC5 by redundant mechanisms, primarily through Nef
and additionally via envelope glycoprotein. Paradoxically, HIV-1 preserves Nef function to …
and additionally via envelope glycoprotein. Paradoxically, HIV-1 preserves Nef function to …
SERINC5 Potently Restricts Retrovirus Infection In Vivo
U Timilsina, S Umthong, B Lynch, A Stablewski… - MBio, 2020 - Am Soc Microbiol
The ser ine inc orporator (SERINC) proteins are multipass transmembrane proteins that
affect sphingolipid and phosphatidylserine synthesis. Human SERINC5 and SERINC3 were …
affect sphingolipid and phosphatidylserine synthesis. Human SERINC5 and SERINC3 were …