Inflammasomes and proteostasis novel molecular mechanisms associated with atrial fibrillation
N Li, BJJM Brundel - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF), the most common progressive and age-related cardiac arrhythmia,
affects millions of people worldwide. AF is associated with common risk factors, including …
affects millions of people worldwide. AF is associated with common risk factors, including …
Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in …
Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
Inflammation has been implicated in atrial fibrillation (AF), a very common and clinically
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
significant cardiac rhythm disturbance, but its precise role remains poorly understood. Work …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation: mechanisms and potential therapeutic implications
Inflammasomes are high molecular weight protein complexes in the cytosol of immune and
other cells that play a critical role in the innate immune system in response to cellular stress …
other cells that play a critical role in the innate immune system in response to cellular stress …
Inflammation, inflammasome activation, and atrial fibrillation: evidence for causation and new therapeutic targets
DR Van Wagoner, MK Chung - Circulation, 2018 - Am Heart Assoc
Markers of inflammation have been linked to atrial fibrillation (AF), but whether inflammation
is causal or merely a marker of increased risk has long been debated. The association …
is causal or merely a marker of increased risk has long been debated. The association …
[HTML][HTML] Inflammation, atrial fibrillation, and the potential role for colchicine therapy
B Varghese, DI Feldman, C Chew, E Valilis… - Heart Rhythm O2, 2021 - Elsevier
Increasing evidence suggests that the “NACHT-LRR and PYD domain-containing protein
3”(NLRP3) inflammasome plays an important role in atherosclerotic cardiovascular disease …
3”(NLRP3) inflammasome plays an important role in atherosclerotic cardiovascular disease …
NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias
Aims Obesity, an established risk factor of atrial fibrillation (AF), is frequently associated with
enhanced inflammatory response. However, whether inflammatory signaling is causally …
enhanced inflammatory response. However, whether inflammatory signaling is causally …
Targeting NLRP3 (nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3) inflammasome in cardiovascular disorders
Z Wang, W Hu, C Lu, Z Ma, S Jiang, C Gu… - … , and vascular biology, 2018 - Am Heart Assoc
Inflammation is an important innate immune response to infection or tissue damage.
Inflammasomes are involved in the onset and development of inflammation. The NLRP3 …
Inflammasomes are involved in the onset and development of inflammation. The NLRP3 …
[HTML][HTML] Sterile inflammation and the NLRP3 inflammasome in cardiometabolic disease
S Cho, F Ying, G Sweeney - biomedical journal, 2023 - Elsevier
Inflammation plays an important role in the pathophysiology of cardiometabolic diseases.
Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP) …
Sterile inflammation, a non-infectious and damage-associated molecular pattern (DAMP) …