Parkinson's disease (PD) is recognized by the accumulation of α-synuclein within neurons.
In contrast to the current ascending theory where α-synuclein would propagate from neuron …

Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite
this, very little is known about the underlying cellular mechanisms. Initially it was thought to …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

Parkinson disease (PD) is a multisystem neurodegenerative disorder clinically characterized
by motor and non-motor (NM) symptoms. The causes of NM symptoms in PD, many of which …

Parkinson's disease is a common neurodegenerative disorder presenting with a variety of
motor and non-motor symptoms. The motor symptoms manifest as a result of the progressive …

It took almost 100 years before a meaningful advance occurred in any basic science
understanding of Parkinson disease (PD) following James Parkinson's description in 1817 …

Important advances in Parkinson disease (PD) in 2015 included a revision of its clinical
diagnostic criteria and a proposal for research criteria defining prodromal PD. Research …

The Parkinson's disease (PD) research field has seen the advent of several promising
biomarkers and a deeper understanding of the clinical features of the disease from the …

The prodromal phase of Parkinson's disease is characterized by aggregation of the
misfolded pathogenic protein α-synuclein in select neural centres, co-occurring with non …

Despite tremendous growth in recent years in our knowledge of the molecular basis of
Parkinson disease (PD) and the molecular pathways of cell injury and death, we remain …