We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …

Enhancer-associated long noncoding RNAs act over long distances and across
chromosomes to activate transcription at distal promoters. Here, we address the latest …

Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment to …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease.
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …

Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …

Super-enhancers are characterized by high levels of Mediator binding and are major
contributors to the expression of their associated genes. They exhibit high levels of local …

Cells communicate with one another to create microenvironments and share resources. One
avenue by which cells communicate is through the action of exosomes. Exosomes are …

The vast majority of the mammalian genome has the potential to express noncoding RNA
(ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3′–5 …

The exosome is an RNA-decay complex that constantly monitors transcription and
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …