Background Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting
considerable attention. In recent years, the causal role between LPR and laryngeal …

Abstract Objective/Hypothesis: Laryngopharyngeal reflux (LPR) is thought to be a significant
risk factor for laryngeal squamous cell carcinoma (SCC), but causality has never been …

Objective Laryngopharyngeal reflux (LPR) is a common affliction that contributes to
laryngeal inflammation, symptoms that impact quality of life, and life‐threatening illnesses …

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the
development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of …

Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …

Outcome Objectives (1) Investigate the role of reflux, specifically pepsin, in
laryngopharyngeal carcinogenesis.(2) Evaluate effects of chronic pepsin exposure on cell …

Background Extra-esophageal carcinogenesis has been widely discussed in relation to the
chronic effects of laryngopharyngeal reflux and most prominently with pepsin historically …

Laryngeal and hypopharyngeal carcinomas are common malignant tumors of the head and
neck, and the incidence of both is increasing. Laryngopharyngeal reflux refers to the …

Nasopharyngeal carcinoma (NPC) has the highest metastatic potential among head and
neck cancers. Distant metastasis is the major cause of treatment failure. The role of …

Objectives Idiopathic subglottic stenosis (iSGS) is commonly characterized by laryngeal
fibrosis thought to arise by epithelia‐mesenchymal transition (EMT) induced by chronic …