Magnetic hydrogel microrobots delivery system for deafness prevention

H Chen, H Zhang, Y Dai, H Zhu, G Hong… - Advanced Functional …, 2023 - Wiley Online Library
Hydrogel microrobots have blazed new avenues for local drug administration, while their
values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic …

Microfluidic preparation of gelatin methacryloyl microgels as local drug delivery vehicles for hearing loss therapy

J Wang, C Wang, Q Wang, Z Zhang… - … Applied Materials & …, 2022 - ACS Publications
Local drug delivery has become an effective method for disease therapy in fine organs
including ears, eyes, and noses. However, the multiple anatomical and physiological …

Adhesive and injectable hydrogel microspheres for inner ear treatment

K Chen, F Wang, R Ding, Z Cai, T Zou, A Zhang, D Guo… - Small, 2022 - Wiley Online Library
The least damaging and most economical method to deliver drugs or carriers into the inner
ear for treatment of disease is through the middle ear. However, the retention of drug in the …

Magnetic injection of nanoparticles into rat inner ears at a human head working distance

A Sarwar, R Lee, DA Depireux… - IEEE Transactions on …, 2012 - ieeexplore.ieee.org
Due to the physics of magnetic fields and forces, any single magnet will always attract or pull-
in magnetically-responsive particles. However, there are a variety of clinical needs where it …

Magnetic nano-particles retrievable biodegradable hydrogel microrobot

D Kim, H Lee, S Kwon, H Choi, S Park - Sensors and Actuators B: Chemical, 2019 - Elsevier
Drug therapy using cancer-targeted drug delivery particles is widely adopted as a general
anti-cancer therapy. In this approach, anticancer drug particles target mainly cancer cells …

Nanomedicine strategies for drug delivery to the ear

CO Pritz, J Dudas, H Rask-Andersen… - …, 2013 - Taylor & Francis
The highly compartmentalized anatomy of the ear aggravates drug delivery, which is used to
combat hearing-related diseases. Novel nanosized drug vehicles are thought to overcome …

Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus

H Lee, H Choi, M Lee, S Park - Biomedical microdevices, 2018 - Springer
Currently, microrobots are receiving attention because of their small size and motility, which
can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel …

Bilayer hydrogel sheet‐type intraocular microrobot for drug delivery and magnetic nanoparticles retrieval

DI Kim, H Lee, SH Kwon, YJ Sung… - Advanced healthcare …, 2020 - Wiley Online Library
By virtue of minimum invasiveness and driving ability using a magnetic field, drug delivery
with the aid of a microrobot has an inherent potential for targeted treatment for the eye. The …

An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles

Z Liang, H Yu, J Lai, L Wen, G Chen - Journal of Controlled Release, 2020 - Elsevier
Biological barriers are the first line of defense against pathogen invasions, but they can also
present as critical obstacles to drug delivery. Despite a variety of strategies have been …

Magnetically actuated drug delivery helical microrobot with magnetic nanoparticle retrieval ability

H Lee, D Kim, S Kwon, S Park - ACS applied materials & …, 2021 - ACS Publications
Therapeutic drug delivery microrobots capable of accurate targeting using an
electromagnetic actuation (EMA) system are being developed. However, these drug delivery …