Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …

Background: Sirtuin 1–7 (SIRT1–7) are deacetylases that are dependent on NAD+ for their
activity. SIRT1 down-regulates p53 activity, increasing lifespan, cell survival, and …

Recent studies in mice have identified single molecules that can delay multiple diseases of
aging and extend lifespan. In theory, such molecules could prevent dozens of diseases …

Resveratrol (RESV) exerts important pharmacological effects on human health: in addition to
its beneficial effects on type 2 diabetes and cardiovascular diseases, it also modulates …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Sirtuin proteins are conserved regulators of aging that have recently emerged as important
modifiers of several diseases which commonly occur later in life such as cancer, diabetes …

Sirtuins are a family of NAD+-dependent deacylases with numerous physiological and
pathological implications, which lately became an attractive therapeutic target. Sirtuin …

The controversy around sirtuins and their functions in aging has drawn in the past few years
as much attention, if not more, from the scientific community and the public as they did when …

Age is the most important risk factor for diseases affecting the Western world, and slowing
age‐related degeneration would greatly improve the quality of human life. In rodents, caloric …

Abstract Sirtuins 1‐7 (SIRT1‐7) belong to the third class of deacetylase enzymes, which are
dependent on NAD+ for activity. Sirtuins activity is linked to gene repression, metabolic …