Use of mixture design in drug-excipient compatibility determinations: Thymol nanoparticles case study

FQ Pires, T Angelo, JKR Silva, LCL Sá-Barreto… - … of pharmaceutical and …, 2017 - Elsevier
The objective of this work was to access thymol-excipient compatibility using an alternative
protocol of mixture design subsidizing the development of nanostructures lipid carriers …

Drug-excipient compatibility testing using a high-throughput approach and statistical design

N Wyttenbach, C Birringer, J Alsenz… - Pharmaceutical …, 2005 - Taylor & Francis
The aim of our research was to develop a miniaturized high throughput drug-excipient
compatibility test. Experiments were planned and evaluated using statistical experimental …

[PDF][PDF] Thermal Analysis as a Useful Tool in Drug-Excipient Compatibilty Studies: The Impact in Pharmaceuticals Products

D Dourado - Biomed. J. Sci. Tech. Res, 2019 - researchgate.net
This mini-review discusses the importance of thermal analysis as a predictive tool for
pharmaceutical stability in the design of drug-excipient compatibility studies. In this regard …

Drug–excipient compatibility screening—role of thermoanalytical and spectroscopic techniques

R Chadha, S Bhandari - Journal of pharmaceutical and biomedical …, 2014 - Elsevier
Estimation of drug–excipient interactions is a crucial step in preformulation studies of drug
development to achieve consistent stability, bioavailability and manufacturability of solid …

Drug-excipient compatibility studies in formulation development: current trends and techniques

VS Dave, RV Haware, NA Sangave… - American Association …, 2015 - fisherpub.sjf.edu
The safety, efficacy, quality and stability of a formulation are the cornerstones of any new
drug development process. In order to consistently maintain these attributes in a finished …

Drug–excipient interaction and incompatibilities

B Gorain, H Choudhury, M Pandey… - Dosage form design …, 2018 - Elsevier
Pharmaceutical excipients are traditionally considered as pharmacologically inert
substances, but, can also actively participate in drug–excipient interactions, viz., physical …

Ensuring Product Stability–Choosing the Right Excipients

N Veronica, PWS Heng, CV Liew - Journal of Pharmaceutical Sciences, 2022 - Elsevier
The stability of pharmaceuticals is an important product quality attribute. Of the known factors
affecting stability, moisture is often perceived as the most common cause of drug …

Compatibility study between lipoic acid with polymers used in controlled drug release systems

PCD Silva, AS Portela, RSC Lima, CP Santana… - Journal of Thermal …, 2016 - Springer
Lipoic acid is derived from octanoic acid and is considered a universal antioxidant for
combating free radicals and regeneration of endogenous antioxidant, as well as acting like …

[HTML][HTML] Drug-excipient compatibility study through a novel vial-in-vial experimental setup: a benchmark study

S Jain, RP Shah - AAPS pharmscitech, 2023 - Springer
Drug-excipient compatibility study (DECS) is one of the critical steps during pre-formulation
studies to select the appropriate excipient to obtain a stable formulation/dosage form. As …

Preformulation: The use of FTIR in compatibility studies

AI Segall - 2019 - notablesdelaciencia.conicet.gov.ar
Studies of active pharmaceutical ingredient (API)-excipient compatibility represent an
important study in the preformulation stage of the development of new dosage forms. The …