Background We previously reported a modification of the CUT&Tag method (NTU-CAT) that
allows genome-wide histone modification analysis in individual preimplantation embryos. In …

Background: We previously reported a modification of the CUT&Tag method (NTU-CAT) that
allows genome-wide histone modification analysis in individual preimplantation embryos. In …

Individual analysis of the epigenome of preimplantation embryos is useful for characterizing
each embryo and for investigating the effects of environmental factors on their epigenome …

Epigenetic studies of rare biological samples like mammalian oocytes and preimplantation
embryos require low input or even single cell epigenomic profiling methods. To reduce …

Background Genome‐wide information on epigenetic modifications in mammalian
preimplantation embryos was an unexplored sanctuary of valuable research insights …

Background Current data indicate that preimplantation genetic screening (PGS) increases
live birth and decreases miscarriage rates. However, high cost has limited its adoption. This …

Chromatin immunoprecipitation coupled with next-generation sequencing (ChIP-seq) has
revolutionized our understanding of chromatin-related biological processes. The method …

STUDY QUESTION Can simultaneous comprehensive chromosome screening (CCS) and
gene expression analysis be performed on the same biopsy of preimplantation human …

Purpose Next-generation sequencing technology like MPS has recently been introduced to
perform comprehensive chromosome screening on human trophectoderm samples for …

Early embryonic development is characterized by drastic changes in chromatin structure that
affects the accessibility of the chromatin. In human, the chromosome reorganization and its …