Methylation of histone H3 lysine 4 (H3K4me) is an intricately regulated posttranslational
modification, which is broadly associated with enhancers and promoters of actively …

The growing list of mutations implicated in monogenic disorders of the developing brain
includes at least seven genes (ARX, CUL4B, KDM5A, KDM5C, KMT2A, KMT2C, KMT2D) …

Histone lysine methyltransferases (KMTs) and demethylases (KDMs) underpin gene
regulation. Here we demonstrate that variants causing haploinsufficiency of KMTs and …

Histone H3 lysine 4 methylation (H3K4me) is extensively regulated by numerous writer and
eraser enzymes in mammals. Nine H3K4me enzymes are associated with …

Mutations in a number of chromatin modifiers are associated with human neurological
disorders. KDM5C, a histone H3 lysine 4 di-and tri-methyl (H3K4me2/3)-specific …

Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

Alterations in RNA levels are frequently reported in brain of subjects diagnosed with autism,
schizophrenia, depression, and other psychiatric diseases, but it remains unclear whether …

Intellectual disability (ID) affects up to 2% of the population world-wide and often coincides
with other neurological conditions such as autism spectrum disorders. Mutations in KDM5C …

Lysine‐specific demethylase 6B (KDM6B) demethylates trimethylated lysine‐27 on histone
H3. The methylation and demethylation of histone proteins affects gene expression during …

Posttranslational modification of histones and related gene regulation are shown to be
affected in an increasing number of neurological disorders. SETD1A is a chromatin …