Targeting the impossible: a review of new strategies against endospores

A Romero-Rodríguez, B Ruiz-Villafán… - Antibiotics, 2023 - mdpi.com
Endospore-forming bacteria are ubiquitous, and their endospores can be present in food, in
domestic animals, and on contaminated surfaces. Many spore-forming bacteria have been …

Bacterial spore-formers: friends and foes

SM Cutting, E Ricca - FEMS Microbiology Letters, 2014 - academic.oup.com
are the only treatments so far developed to avoid recurrent infections (van Nood et al.,
2013). Capable of withstanding heat, desiccation and noxious chemicals, spores transmit C …

Opportunities for Nanomedicine in Clostridioides difficile Infection

PW Wang, WT Lee, YN Wu, DB Shieh - Antibiotics, 2021 - mdpi.com
Clostridioides difficile, a spore-forming bacterium, is a nosocomial infectious pathogen
which can be found in animals as well. Although various antibiotics and disinfectants were …

[HTML][HTML] Inhibition of spores to prevent the recurrence of Clostridioides difficile infection-A possibility or an improbability?

CW Chiu, PJ Tsai, CC Lee, WC Ko, YP Hung - Journal of Microbiology …, 2021 - Elsevier
Clostridioides difficile is one of the most common nosocomial gastrointestinal pathogens,
and recurrence is a problematic issue because approximately 20–30% of patients …

Endospores, sporulation and germination

E Abel-Santos - Molecular medical microbiology, 2015 - Elsevier
Endospore-forming bacteria cause a range of important clinical infections. In this chapter,
recent advances in endospore research are summarized. The function of endospore …

Endophytes: a uniquely tailored source of potential antibiotic adjuvants

AY Moussa - Archives of Microbiology, 2024 - Springer
Multidrug microbial resistance is risking an annual loss of more than 10 million people'lives
by 2050. Solutions include the rational use of antibiotics and the use of drugs that reduce …

[HTML][HTML] Endophytic bacteria as a source of novel antibiotics: an overview

A Christina, V Christapher, SJ Bhore - Pharmacognosy reviews, 2013 - ncbi.nlm.nih.gov
World human population is increasing with an alarming rate; and a variety of new types of
health issues are popping up. For instance, increase in number of drug-resistant bacteria is …

Vancomycin-Loaded Nanoparticles Enhance Sporicidal and Antibacterial Efficacy for Clostridium difficile Infection

YH Chen, TJ Li, BY Tsai, LK Chen, YH Lai… - Frontiers in …, 2019 - frontiersin.org
Current antibiotic treatments fail to eliminate the Clostridium difficile (C. difficile) spores and
induce dysbiosis and intestinal inflammation via off-target effect, which causes refractory C …

Assessing the activity of microbicides against bacterial spores: knowledge and pitfalls

MJ Leggett, P Setlow, SA Sattar… - Journal of Applied …, 2016 - academic.oup.com
Bacterial endospores (spores) have a higher intrinsic resistance to microbicides as
compared to other microbial forms, most likely due to their impermeable outer layers and low …

Novel targets for antibiotics-an update

RE Isaacson - Expert Opinion on Investigational Drugs, 1997 - Taylor & Francis
The emergence of widespread antibiotic resistance as an impediment in the treatment of
bacterial diseases is of growing concern. In some instances, clinicians are left with few or no …