The epithelium provides a crucial barrier to infection and its integrity requires efficient wound
healing. Bacterial cells and secretomes from a subset of tested species of bacteria inhibited …

The healthy cornea is remarkably resistant to infection, quickly clearing deliberately
inoculated bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus …

Pseudomonas aeruginosa keratitis is an acute sight-threatening infection. We previously
reported that human tear fluid could protect individual human corneal epithelial cells in vitro …

Purpose Pseudomonas aeruginosa keratitis is a severe ocular infection that can lead to
perforation of the cornea. In this study we evaluated the role of bacterial quorum sensing in …

Biofilms are aggregates of bacteria encased in an extracellular polymer matrix that acts as a
diffusion barrier protecting the microbial community. Bacterial communication occurs by …

purpose. The scarified cornea keratitis model was modified to study Pseudomonas
aeruginosa infection of healing corneal epithelium. The new model was then used to study …

Purpose.: Mechanisms determining epithelial resistance versus susceptibility to microbial
traversal in vivo remain poorly understood. Here, a novel murine model was used to explore …

Pseudomonas aeruginosa is a leading cause of human morbidity and mortality that often
targets epithelial surfaces. Host immunocompromise, or the presence of indwelling medical …

Both cytotoxic and invasive strains of Pseudomonas aeruginosa can damage corneal
epithelial cells in vitro, but neither can infect healthy corneas in vivo. We tested the …

Re-epithelialization is an essential step of wound healing involving three overlapping
keratinocyte functions: migration, proliferation and differentiation. While quorum sensing …