Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and
abnormal deposits of aggregated amyloid-β in the brain. Recent genome-wide association …

ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been
detected in macrophages, microglia, and neurons. ABCA7 promotes efflux of lipids from …

The ATP-binding cassette (ABC) reporter family functions to regulate the homeostasis of
phospholipids and cholesterol in the central nervous system, as well as peripheral tissues …

ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain. Recent
genome-wide association studies (GWAS) identify ABCA7 single nt polymorphisms (SNPs) …

Alzheimer's disease (AD) is the most common type of neurodegenerative disease and its
pathogenesis is still unclear. Genetic factors are thought to account for a large proportion of …

The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility
factor of late onset Alzheimer disease in genome-wide association studies. ABCA7 has …

Carrying premature termination codons in 1 allele of the ABCA7 gene is associated with an
increased risk for Alzheimer's disease (AD). While the primary function of ABCA7 is to …

Brain cholesterol homeostasis is regulated by a group of proteins called ATP-binding
cassette subfamily A (ABCA) transporters. Certain ABCA transporters regulate amyloid-β …

The role of ABCA7 in brain homeostasis and Alzheimer's disease (AD) is currently under
intense scrutiny, since it has been reported that polymorphisms in the Abca7 gene and a …

Abstract ATP-binding cassette A7 (ABCA7) gene has recently been identified as a strong
genetic locus associated with late-onset Alzheimer's disease (LOAD) through genome-wide …