In an effort to develop potent and selective antitumor agents, a series of 1, 4-
naphthoquinone oxime derivatives were designed and synthesized. The cytotoxicity of these …

Abstract A series of 6-substituted 1, 4-naphthoquinone oxime derivatives were synthesized
and evaluated for their in vitro cytotoxicity against four cancer cell lines and one normal cell …

To establish the structure-activity relationship of 5-hydroxy-1, 4-naphthoquinones toward
anticancer activity, a series of its derivatives were prepared and tested for the activity (IC 50 …

To examine the effect of hydrophobicity on the anticancer activity of 1, 4-naphthoquinone
derivatives, a series of compounds bearing a 2-O-alkyl-, 3-C-alkyl-or 2/3-N-morpholinoalkyl …

Abstract Thirty six 5, 8-dimethoxy-1, 4-naphthoquinone derivatives, which bear unsaturated
alkyl side chain with ester bond, were synthesized and tested cytotoxic activity on L1210 …

All of 13 (E)-6-(1-alkyloxyiminomethyl)-5, 8-dimethoxy-1, 4-naphthoquinone derivatives
synthesized showed high ED50 values, ranging from 0.1 to 0.3 μg/mL against L1210 cells …

Twelve novel naphthoquinone esters containing cyclopentyl and cyclohexyl substituents at
C-2′ of the propyl chain were synthesized by starting from 1-hydroxy-2-naphthoic acid via …

Naphthoquinones are widely distributed in nature and many clinically important antitumor
drugs containing a quinone moiety, such as anthracyclines, mitoxantrones and saintopin …

In the present study substituted 1, 2-naphthoquinones were synthesized, purified and
characterized by spectroscopic studies (UV, FT-IR, 1 H NMR, 13 C NMR and elemental …

Fourteen new naphthoquinone aliphatic amides and seventeen naphthoquinone aliphatic
esters were synthesized in nine to ten steps from 1-hydroxy-2-naphthoic acid with 9–25 …