Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study

W Rong, J Li, D Pan, Q Zhou, Y Zhang, Q Lu, L Wang… - Biomolecules, 2022 - mdpi.com
Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous
studies suggested that cardiac protection by leonurine during myocardial ischemia …

Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy

W Rong, J Li, L Wang, S Luo, T Liang… - Frontiers in …, 2022 - frontiersin.org
Background Leonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases.
As the most representative component in the herb, leonurine has attracted increasing …

Leonurine improves ischemia-induced myocardial injury through antioxidative activity

XH Liu, LL Pan, PF Chen, YZ Zhu - Phytomedicine, 2010 - Elsevier
The present study was designed to investigate the protective effects of 4-guanidino-n-butyl
syringate (leonurine), a compound in Herba Leonuri (HL) on ischemic rat heart to determine …

Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway Corrigendum in/10.3892 …

L Xu, X Jiang, F Wei, H Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Leonurine is a compound derived from Herba leonuri, which has been reported to protect
cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects. The present …

[HTML][HTML] Leonurine affected homocysteine‐methionine metabolism based on metabolomics and gut microbiota studies of clinical trial samples

J Liao, R Suguro, X Zhao, Y Yu, Y Cui… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Dear Editor, Cardiovascular disease (CVD) remains the leading cause of mortality globally,
taking several millions of lives every year. Various risk factors for CVD have been identified …

Discovery of Leonuri and therapeutical applications: from bench to bedside

YZ Zhu, W Wu, Q Zhu, X Liu - Pharmacology & therapeutics, 2018 - Elsevier
Despite several advances in percutaneous coronary intervention and the discovery of new
drugs, the incidence of myocardial infarction and deaths due to cardiovascular diseases …

Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction

XH Liu, LL Pan, QH Gong, YZ Zhu - European journal of pharmacology, 2010 - Elsevier
Leonurine, an alkaloid typically found in Herba leonuri, is known to have both antioxidant
and cardioprotective properties. In the present study, we investigated the cardioprotective …

Beneficial effects of oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches

J Zhang, Y Zhou, Y Sun, H Yan, W Han, X Wang… - European Journal of …, 2019 - Elsevier
Oridonin is a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, a well-known
herbal tea in China with many health benefits. To provide a better understanding of the …

[HTML][HTML] Combined transcriptomics and metabolomics to elucidate the underlying beneficial mechanisms of L-Theanine in mitigating obesity-induced cardiac injury in …

C Fang, Y Shen, F Wang, J Zhang, C Liu, F Luo… - Journal of Functional …, 2024 - Elsevier
Abstract L-theanine (L-Thea), an amino acid that is found in tea, possesses significant
nutraceutical properties. This study aimed to investigate the anti-cardiac injury caused by …

Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection

M Jiang, Q Wang, J Chen, Y Wang, G Fan, Y Zhu - Scientific reports, 2017 - nature.com
Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small
molecule metabolites in cells, tissues, or whole organisms, the application of which has led …