Cardioprotective Mechanism of Leonurine against Myocardial Ischemia through a Liver–Cardiac Crosstalk Metabolomics Study
W Rong, J Li, D Pan, Q Zhou, Y Zhang, Q Lu, L Wang… - Biomolecules, 2022 - mdpi.com
Leonurine has been shown to have excellent anti-myocardial ischemia effects. Our previous
studies suggested that cardiac protection by leonurine during myocardial ischemia …
studies suggested that cardiac protection by leonurine during myocardial ischemia …
Investigation of the protective mechanism of leonurine against acute myocardial ischemia by an integrated metabolomics and network pharmacology strategy
W Rong, J Li, L Wang, S Luo, T Liang… - Frontiers in …, 2022 - frontiersin.org
Background Leonurus japonicus Houtt has an obvious efficacy on cardiovascular diseases.
As the most representative component in the herb, leonurine has attracted increasing …
As the most representative component in the herb, leonurine has attracted increasing …
Leonurine improves ischemia-induced myocardial injury through antioxidative activity
The present study was designed to investigate the protective effects of 4-guanidino-n-butyl
syringate (leonurine), a compound in Herba Leonuri (HL) on ischemic rat heart to determine …
syringate (leonurine), a compound in Herba Leonuri (HL) on ischemic rat heart to determine …
Leonurine protects cardiac function following acute myocardial infarction through anti‑apoptosis by the PI3K/AKT/GSK3β signaling pathway Corrigendum in/10.3892 …
L Xu, X Jiang, F Wei, H Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Leonurine is a compound derived from Herba leonuri, which has been reported to protect
cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects. The present …
cardiac tissue against ischemic injury via antioxidant and anti‑apoptosis effects. The present …
[HTML][HTML] Leonurine affected homocysteine‐methionine metabolism based on metabolomics and gut microbiota studies of clinical trial samples
J Liao, R Suguro, X Zhao, Y Yu, Y Cui… - Clinical and …, 2021 - ncbi.nlm.nih.gov
Dear Editor, Cardiovascular disease (CVD) remains the leading cause of mortality globally,
taking several millions of lives every year. Various risk factors for CVD have been identified …
taking several millions of lives every year. Various risk factors for CVD have been identified …
Discovery of Leonuri and therapeutical applications: from bench to bedside
Despite several advances in percutaneous coronary intervention and the discovery of new
drugs, the incidence of myocardial infarction and deaths due to cardiovascular diseases …
drugs, the incidence of myocardial infarction and deaths due to cardiovascular diseases …
Leonurine (SCM-198) improves cardiac recovery in rat during chronic infarction
Leonurine, an alkaloid typically found in Herba leonuri, is known to have both antioxidant
and cardioprotective properties. In the present study, we investigated the cardioprotective …
and cardioprotective properties. In the present study, we investigated the cardioprotective …
Beneficial effects of oridonin on myocardial ischemia/reperfusion injury: insight gained by metabolomic approaches
J Zhang, Y Zhou, Y Sun, H Yan, W Han, X Wang… - European Journal of …, 2019 - Elsevier
Oridonin is a diterpenoid isolated from Rabdosia rubescens (Hemsl.) Hara, a well-known
herbal tea in China with many health benefits. To provide a better understanding of the …
herbal tea in China with many health benefits. To provide a better understanding of the …
[HTML][HTML] Combined transcriptomics and metabolomics to elucidate the underlying beneficial mechanisms of L-Theanine in mitigating obesity-induced cardiac injury in …
C Fang, Y Shen, F Wang, J Zhang, C Liu, F Luo… - Journal of Functional …, 2024 - Elsevier
Abstract L-theanine (L-Thea), an amino acid that is found in tea, possesses significant
nutraceutical properties. This study aimed to investigate the anti-cardiac injury caused by …
nutraceutical properties. This study aimed to investigate the anti-cardiac injury caused by …
Comparative metabonomics of Wenxin Keli and Verapamil reveals differential roles of gluconeogenesis and fatty acid β-oxidation in myocardial injury protection
Metabonomics/metabolomics is a rapid technology for comprehensive profiling of small
molecule metabolites in cells, tissues, or whole organisms, the application of which has led …
molecule metabolites in cells, tissues, or whole organisms, the application of which has led …