Targeting type I PRMTs as promising targets for the treatment of pulmonary disorders: Asthma, COPD, lung cancer, PF, and PH
S Zhou, Q Zhang, H Yang, Y Zhu, X Hu, G Wan, L Yu - Life Sciences, 2024 - Elsevier
Pulmonary disorders, including asthma, chronic obstructive pulmonary disease (COPD),
pulmonary fibrosis (PF), pulmonary hypertension (PH), and lung cancer, seriously impair the …
pulmonary fibrosis (PF), pulmonary hypertension (PH), and lung cancer, seriously impair the …
Arginine methylation and respiratory disease
B Zhang, Y Guan, D Zeng, R Wang - Translational Research, 2024 - Elsevier
Arginine methylation, a vital post-translational modification, plays a pivotal role in numerous
cellular functions such as signal transduction, DNA damage response and repair, regulation …
cellular functions such as signal transduction, DNA damage response and repair, regulation …
An updated patent review of protein arginine N-methyltransferase inhibitors (2019–2022)
J Dong, J Duan, Z Hui, C Garrido, Z Deng… - Expert Opinion on …, 2022 - Taylor & Francis
Protein arginine methyltransferases (PRMTs), enzymes catalyzing the methylation of target
proteins, play an essential role in maintaining functional homeostasis in normal physiology …
proteins, play an essential role in maintaining functional homeostasis in normal physiology …
Protein arginine methyltransferases (PRMTs): promising targets for the treatment of pulmonary disorders
D Zakrzewicz, A Zakrzewicz, KT Preissner… - International journal of …, 2012 - mdpi.com
Protein arginine methylation is a novel posttranslational modification that plays a pivotal role
in a variety of intracellular events, such as signal transduction, protein-protein interaction …
in a variety of intracellular events, such as signal transduction, protein-protein interaction …
A patent review of arginine methyltransferase inhibitors (2010–2018)
ABSTRACT Introduction: Protein arginine methyltransferases (PRMTs) are fundamental
enzymes that specifically modify the arginine residues of versatile substrates in cells. The …
enzymes that specifically modify the arginine residues of versatile substrates in cells. The …
Current development of protein arginine methyltransferase inhibitors
Protein arginine methyltransferases (PRMTs) methylate numerous nuclear and cytoplasmic
substrates and play key roles in various biological processes, including cell death, cell cycle …
substrates and play key roles in various biological processes, including cell death, cell cycle …
A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases
Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological
processes. Overexpression of PRMTs has been implicated in various human diseases …
processes. Overexpression of PRMTs has been implicated in various human diseases …
Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity
GM Kong, M Yu, Z Gu, Z Chen, RM Xu, D O'Bryant… - PloS one, 2017 - journals.plos.org
Protein arginine methyltransferase 5 (PRMT5) plays critical roles in a wide variety of
biological processes, including tumorigenesis. By screening a library of small chemical …
biological processes, including tumorigenesis. By screening a library of small chemical …
Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions
C Tong, X Chang, F Qu, J Bian, J Wang, Z Li… - European Journal of …, 2024 - Elsevier
Protein methylation is a post-translational modification (PTM) that organisms undergo. This
process is considered a part of epigenetics research. In recent years, there has been an …
process is considered a part of epigenetics research. In recent years, there has been an …
Expression profiling of protein arginine methyltransferase (Prmt) isoforms in chronic obstructive pulmonary disease (COPD)
AO Yildirim, M Konigshoff, Q Wang… - … AND IN INJURY, 2010 - atsjournals.org
COPD is defined by tissue remodelling in the smaller airways and emphysema, which is
characterized by airspace enlargement and reduced gas exchange area. Therefore, both for …
characterized by airspace enlargement and reduced gas exchange area. Therefore, both for …