Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses
MN Cabili, C Trapnell, L Goff, M Koziol… - Genes & …, 2011 - genesdev.cshlp.org
Large intergenic noncoding RNAs (lincRNAs) are emerging as key regulators of diverse
cellular processes. Determining the function of individual lincRNAs remains a challenge …
cellular processes. Determining the function of individual lincRNAs remains a challenge …
Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs
MJ Hangauer, IW Vaughn, MT McManus - PLoS genetics, 2013 - journals.plos.org
Known protein coding gene exons compose less than 3% of the human genome. The
remaining 97% is largely uncharted territory, with only a small fraction characterized. The …
remaining 97% is largely uncharted territory, with only a small fraction characterized. The …
Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals
Long intergenic noncoding RNAs (lincRNAs) play diverse regulatory roles in human
development and disease, but little is known about their evolutionary history and constraint …
development and disease, but little is known about their evolutionary history and constraint …
Principles of long noncoding RNA evolution derived from direct comparison of transcriptomes in 17 species
H Hezroni, D Koppstein, MG Schwartz, A Avrutin… - Cell reports, 2015 - cell.com
The inability to predict long noncoding RNAs from genomic sequence has impeded the use
of comparative genomics for studying their biology. Here, we develop methods that use RNA …
of comparative genomics for studying their biology. Here, we develop methods that use RNA …
The landscape of long noncoding RNAs in the human transcriptome
Long noncoding RNAs (lncRNAs) are emerging as important regulators of tissue physiology
and disease processes including cancer. To delineate genome-wide lncRNA expression …
and disease processes including cancer. To delineate genome-wide lncRNA expression …
[HTML][HTML] Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution
Thousands of long intervening noncoding RNAs (lincRNAs) have been identified in
mammals. To better understand the evolution and functions of these enigmatic RNAs, we …
mammals. To better understand the evolution and functions of these enigmatic RNAs, we …
lncRNAtor: a comprehensive resource for functional investigation of long non-coding RNAs
Motivation: A number of long non-coding RNAs (lncRNAs) have been identified by deep
sequencing methods, but their molecular and cellular functions are known only for a limited …
sequencing methods, but their molecular and cellular functions are known only for a limited …
The functions and unique features of long intergenic non-coding RNA
JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
Long noncoding RNA (lincRNA), a new paradigm in gene expression control
Long intergenic non-coding RNAs (lincRNAs) are defined as RNA transcripts that are longer
than 200 nucleotides. By definition, these RNAs must not have open reading frames that …
than 200 nucleotides. By definition, these RNAs must not have open reading frames that …
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
The human genome contains many thousands of long noncoding RNAs (lncRNAs). While
several studies have demonstrated compelling biological and disease roles for individual …
several studies have demonstrated compelling biological and disease roles for individual …