On the Origin and Evolution of the Mosquito Male-determining Factor Nix

JK Biedler, A Aryan, Y Qi, A Wang… - Molecular Biology …, 2024 - academic.oup.com
The mosquito family Culicidae is divided into 2 subfamilies named the Culicinae and
Anophelinae. Nix, the dominant male-determining factor, has only been found in the …

[HTML][HTML] Nix is a male-determining factor in the Asian tiger mosquito Aedes albopictus

P Liu, B Jin, X Li, Y Zhao, J Gu, JK Biedler, ZJ Tu… - Insect biochemistry and …, 2020 - Elsevier
The initial signal that governs sex determination is highly variable among insects. A
homolog of Nix, the male-determining factor in Aedes aegypti, was previously found in the …

Sex determination in mosquitoes

JK Biedler, Z Tu - Advances in Insect Physiology, 2016 - Elsevier
Sexual reproduction is critical to the survival and evolution of many organisms including
mosquitoes. Sex determination in insects is often initiated by a fast-evolving primary signal …

A male-determining factor in the mosquito Aedes aegypti

AB Hall, S Basu, X Jiang, Y Qi, VA Timoshevskiy… - Science, 2015 - science.org
Sex determination in the mosquito Aedes aegypti is governed by a dominant male-
determining factor (M factor) located within a Y chromosome–like region called the M locus …

The Nix locus on the male-specific homologue of chromosome 1 in Aedes albopictus is a strong candidate for a male-determining factor

LM Gomulski, M Mariconti, A Di Cosimo, F Scolari… - Parasites & vectors, 2018 - Springer
Background Global concern over the rapid expansion of the Asian tiger mosquito, Aedes
albopictus, and its vector competence has highlighted an urgent need to improve currently …

femaleless controls sex determination and dosage compensation pathways in females of Anopheles mosquitoes

E Krzywinska, L Ferretti, J Li, JC Li, CH Chen… - Current Biology, 2021 - cell.com
The insect sex determination and the intimately linked dosage compensation pathways
represent a challenging evolutionary puzzle that has been solved only in Drosophila …

Nix confers heritable sex-conversion in Aedes aegypti and myo-sex is needed for male flight

A Aryan, M Anderson, JK Biedler, Y Qi, JM Overcash… - bioRxiv, 2019 - biorxiv.org
A dominant and hemizygous male-determining locus (M locus) establishes the male sex
(M/m) in the yellow fever mosquito, Aedes aegypti. Nix is a male-determining factor (M …

Nix alone is sufficient to convert female Aedes aegypti into fertile males and myo-sex is needed for male flight

A Aryan, MAE Anderson, JK Biedler… - Proceedings of the …, 2020 - National Acad Sciences
A dominant male-determining locus (M-locus) establishes the male sex (M/m) in the yellow
fever mosquito, Aedes aegypti. Nix, a gene in the M-locus, was shown to be a male …

Molecular tools to create new strains for mosquito sexing and vector control

I Häcker, MF Schetelig - Parasites & vectors, 2018 - Springer
Vector control programs based on population reduction by matings with mass-released
sterile insects require the release of only male mosquitoes, as the release of females, even if …

Characterization of the doublesex gene within the Culex pipiens complex suggests regulatory plasticity at the base of the mosquito sex determination cascade

DC Price, A Egizi, DM Fonseca - BMC evolutionary biology, 2015 - Springer
Background The doublesex gene controls somatic sexual differentiation of many metazoan
species, including the malaria mosquito Anopheles gambiae and the dengue and yellow …