Preclinical murine models of chronic obstructive pulmonary disease

R Vlahos, S Bozinovski - European journal of pharmacology, 2015 - Elsevier
Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health
burden and is the 4th leading cause of death worldwide. It is believed that an exaggerated …

Animal models of chronic obstructive pulmonary disease

M Fricker, A Deane, PM Hansbro - Expert opinion on drug …, 2014 - Taylor & Francis
Introduction: Chronic obstructive pulmonary disease (COPD) is a leading global cause of
mortality and chronic morbidity. Inhalation of cigarette smoke is the principal risk factor for …

Recent advances in pre-clinical mouse models of COPD

R Vlahos, S Bozinovski - Clinical science, 2014 - portlandpress.com
COPD (chronic obstructive pulmonary disease) is a major incurable global health burden
and will become the third largest cause of death in the world by 2020. It is currently believed …

Modelling COPD in mice

R Vlahos, S Bozinovski, RC Gualano, M Ernst… - Pulmonary …, 2006 - Elsevier
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airflow
limitation, neutrophilic inflammation, macrophage accumulation, and the production of …

What can in vitro models of COPD tell us?

DI Krimmer, BGG Oliver - Pulmonary pharmacology & therapeutics, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterised
by chronic bronchitis, largely irreversible remodelling of the small airways, and …

[HTML][HTML] Understanding the relevance of the mouse cigarette smoke model of COPD: peering through the smoke

RW Vandivier, M Ghosh - American Journal of Respiratory Cell and …, 2017 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is one of the most important threats to public
health because of its prevalence, economic cost, and impact on death and disability …

Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)

P Upadhyay, CW Wu, A Pham, AA Zeki… - Journal of Toxicology …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

Animal models of COPD: W hat do they tell us?

B Jones, C Donovan, G Liu, HM Gomez… - …, 2017 - Wiley Online Library
ABSTRACT COPD is a major cause of global mortality and morbidity but current treatments
are poorly effective. This is because the underlying mechanisms that drive the development …

Cigarette smoke exposure as a model of inflammation associated with COPD

S Eltom, C Stevenson, MA Birrell - Current protocols in …, 2013 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation resulting from inflammation‐driven pathologies in the lungs that are a …

Models for COPD involving cigarette smoke

PA Martorana, E Cavarra, M Lucattelli… - Drug Discovery Today …, 2006 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and
mortality throughout the world. Its impact has resulted in dynamic research into the …