Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

Adipokines represent likely candidates to mediate the increased breast cancer risk and the
enhanced progression associated with obesity. Other contributors to obesity-related cancer …

Highlights•Obesity is a pandemic condition associated with both risk and prognosis of breast
cancer.•The adipokine leptin is a plausible molecular link between obesity and breast …

High plasma levels of leptin, a major adipocytokine produced by adipocytes, are correlated
with increased fat mass in obese state. Leptin is emerging as a key candidate molecule …

More than one million new cases of breast cancer are diagnosed worldwide each year and
more than 400,000 deaths are caused by the disease. The origin of this pathology is …

Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …

The adipocyte‐derived peptide leptin acts through binding to specific membrane receptors,
of which six isoforms (obRa‐f) have been identified up to now. Binding of leptin to its …

Obesity is associated with an increased risk of breast cancer. A number of adipocytokines
are increased in obesity causing low-level chronic inflammation associated with an …

Despite accumulating evidence suggesting a positive correlation between leptin levels,
obesity, post-menopause and breast cancer incidence, our current knowledge on the …

Breast cancer is one of the most common cancers and a leading cause of cancer death in
women worldwide. Incidences of breast cancer are substantially higher among …