Postovulatory oocyte aging has a major influence on the development potential of embryos.
Many antioxidants can delay oocyte aging by regulating the expression of SIRT1. However …

The quality of metaphase II oocytes will undergo a time-dependent deterioration following
ovulation as the result of the oocyte aging process. In this study, we determined that the …

Aims Sirtuins have been implicated in the aging process, however, the functions of SIRT2 in
post-maturation aging of oocytes are not fully understood. The purpose of the present …

Abstract Sirtuin-3 (SIRT3), the main deacetylase in the mitochondria, maintains cellular
energy metabolism and redox balance by deacetylating mitochondrial proteins in a NAD+ …

It has been well recognized that oocyte quality declines in aging animals. However, to date,
the underlying mechanism remains to be explored. In the present study, we report that …

SIRT6, the sixth member of the sirtuin family proteins, has been characterized as a crucial
regulator in multiple molecular pathways related to aging, including genome stability, DNA …

Abstract STUDY QUESTION Is SIRT1 involved in the oxidative stress (OS) response in
mouse oocytes? SUMMARY ANSWER SIRT1 plays a pivotal role in the adaptive response …

The quality of oocytes determines their development competence, which will be rapidly lost if
the oocytes are not fertilized at the proper time after ovulation. SIRT1, one of the sirtuin …

Sirtuins have been widely reported to be involved in multiple biological processes. However,
their function during pig oocyte aging has not been reported yet. Here, we first identify that …

SIRT2, a member of the sirtuin family, has been recently shown to exert important effects on
mitosis and/or metabolism. However, its roles in oocyte maturation have not been fully …