A key mechanism of tumor resistance to immune cells is mediated by expression of peptide-
loaded HLA class I molecule (HLA-E) in tumor cells, which suppresses NK cell activity via …

Tumor-infiltrating CD8 T cells were found to frequently express the inhibitory receptor
NKG2A, particularly in immune-reactive environments and after therapeutic cancer …

Human natural killer (NK) cells are cytotoxic effector cells that are increasingly harnessed in
cancer immunotherapy. NKG2A/CD94 is an inhibitory receptor on NK cells that has …

NKG2D is a recently described activating receptor expressed by both NK cells and CTL. In
this study we investigated the role of NKG2D in the natural cytolysis mediated by NK cell …

In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer
(NK) cells and CD8+ T cells. It form heterodimer receptors with CD94, and targets the …

Ligands of the prototypical activating NK receptor NKG2D render cancer cells susceptible to
NK cell-mediated cytolysis if expressed at sufficiently high levels. However, malignant cells …

Natural killer cells are key cells of the innate immune system. Natural killer cell receptor
repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like …

Several evidences suggest that NK cells can patrol the body and eliminate tumors in their
initial phases but may hardly control established solid tumors. Multiple factors, including the …

Natural killer (NK) cells have originally been identified based on their capacity to kill
transformed cells in a seemingly non-specific fashion. Over the last 15 years, knowledge on …

Ligands for the NKG2D stimulatory receptor are frequently upregulated on tumor lines,
rendering them sensitive to natural killer (NK) cells, but the role of NKG2D in tumor …