Noise-induced loss of hair cells and cochlear synaptopathy are mediated by the activation of AMPK
K Hill, H Yuan, X Wang, SH Sha - Journal of Neuroscience, 2016 - Soc Neuroscience
Noise-induced hearing loss (NIHL) is a major unresolved public health problem. Here, we
investigate pathomechanisms of sensory hair cell death and suggest a novel target for …
investigate pathomechanisms of sensory hair cell death and suggest a novel target for …
Traumatic-noise-induced hair cell death and hearing loss is mediated by activation of CaMKKβ
F Wu, K Hill, Q Fang, Z He, H Zheng, X Wang… - Cellular and Molecular …, 2022 - Springer
Abstract Background The Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs)
are serine/threonine-directed protein kinases that are activated following increases in …
are serine/threonine-directed protein kinases that are activated following increases in …
[HTML][HTML] Noise-induced loss of sensory hair cells is mediated by ROS/AMPKα pathway
F Wu, H Xiong, S Sha - Redox biology, 2020 - Elsevier
The formation of reactive oxygen species (ROS) is a well-documented process in noise-
induced hearing loss (NIHL). We have also previously shown that activation of 5'adenosine …
induced hearing loss (NIHL). We have also previously shown that activation of 5'adenosine …
Prevention of noise-induced hearing loss by calpain inhibitor MDL-28170 is associated with upregulation of PI3K/Akt survival signaling pathway
R Lai, Q Fang, F Wu, S Pan, K Haque… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Noise-induced calcium overload in sensory hair cells has been well
documented as an early step in the pathogenesis of noise-induced hearing loss (NIHL) …
documented as an early step in the pathogenesis of noise-induced hearing loss (NIHL) …
Receptor-interacting protein kinases modulate noise-induced sensory hair cell death
HW Zheng, J Chen, SH Sha - Cell Death & Disease, 2014 - nature.com
Receptor-interacting protein (RIP) kinases promote the induction of necrotic cell death
pathways. Here we investigated signaling pathways in outer hair cells (OHCs) of adult male …
pathways. Here we investigated signaling pathways in outer hair cells (OHCs) of adult male …
Acoustic overstimulation activates 5′-AMP-activated protein kinase through a temporary decrease in ATP level in the cochlear spiral ligament prior to permanent …
R Nagashima, T Yamaguchi, N Kuramoto… - Neurochemistry …, 2011 - Elsevier
Inner ear disorders are known to be elicited by mitochondrial dysfunction, which decreases
the ATP level in the inner ear. 5′-AMP-activated protein kinase (AMPK) is a …
the ATP level in the inner ear. 5′-AMP-activated protein kinase (AMPK) is a …
[HTML][HTML] CFTR potentiator ivacaftor protects against noise-induced hair cell loss by increasing Nrf2 and reducing oxidative stress
F Wu, R Hu, X Huang, J Lou, Z Cai, G Chen… - Biomedicine & …, 2023 - Elsevier
Over-production of reactive oxygen species (ROS) in the inner ear can be triggered by a
variety of pathological events identified in animal models after traumatic noise exposure. Our …
variety of pathological events identified in animal models after traumatic noise exposure. Our …
Increased sensitivity to noise-induced hearing loss by blockade of endogenous PI3K/Akt signaling
J Chen, H Yuan, AE Talaska, K Hill, SH Sha - Journal of the Association …, 2015 - Springer
Abstract The PI3K/Akt signaling pathway is involved in mediating survival of sensory hair
cells. Here, we investigated the involvement of PI3K/Akt in noise-induced hearing loss in …
cells. Here, we investigated the involvement of PI3K/Akt in noise-induced hearing loss in …
AMP‐activated protein kinase in BK‐channel regulation and protection against hearing loss following acoustic overstimulation
M Föller, M Jaumann, J Dettling, A Saxena… - The FASEB …, 2012 - Wiley Online Library
The energy‐sensing AMP‐activated serine/threonine protein kinase (AMPK) confers cell
survival in part by stimulation of cellular energy production and limitation of cellular energy …
survival in part by stimulation of cellular energy production and limitation of cellular energy …
Treatment with calcineurin inhibitor FK506 attenuates noise-induced hearing loss
ZH He, S Pan, HW Zheng, QJ Fang, K Hill… - Frontiers in Cell and …, 2021 - frontiersin.org
Attenuation of noise-induced hair cell loss and noise-induced hearing loss (NIHL) by
treatment with FK506 (tacrolimus), a calcineurin (CaN/PP2B) inhibitor used clinically as an …
treatment with FK506 (tacrolimus), a calcineurin (CaN/PP2B) inhibitor used clinically as an …