Background Whole cell-catalyzed biotransformation is a clear process option for the
production of chiral alcohols via enantioselective reduction of precursor ketones. A wide …

Wild-type Candida tenuisxylose reductase and two Trp-23 mutants thereof catalyze NADH-
dependent reduction of a homologous series of aromatic α-keto esters with absolute pseudo …

Abstract Chiral 1‐(o‐chlorophenyl)‐ethanols are key intermediates in the synthesis of
chemotherapeutic substances. Enantioselective reduction of o‐chloroacetophenone is a …

Enzymes are able to perform reactions under mild conditions, eg, pH and temperature, with
remarkable chemo-, regio-, and stereoselectivity. Due to this feature the number of …

Pure chiral molecules are needed in the pharmaceutical and chemical industry as
intermediates for the production of drugs or fine chemicals. Microorganisms represent an …

We report on the development of a whole‐cell biocatalytic system based on the popular host
Saccharomyces cerevisiae that shows programmable performance and good atom economy …

A pilot scale whole cell process was developed for the enantioselective 1, 2‐reduction of
prochiral α, β‐unsaturated ketone to (R) allylic alcohol using Candida chilensis. Initial …

Lactobacillus brevis alcohol dehydrogenase (Lb-ADH) catalyzes reduction of prochiral
carbonyl compounds to chiral alcohol and meanwhile consumes its cofactor NADH into …

In this work, genome hunting strategy was adopted in screening for reductases from
Candida glabrata. A total of 37 putative reductases were successfully expressed in E. coli …

In this study, a new strategy was developed for efficient synthesis of chiral aryl alcohols
mediated by permeabilizing whole-cell catalyzed bioreduction. The permeabilized …