Main role of antibodies in demyelination and axonal damage in Multiple Sclerosis

Ú Muñoz Morón, C Sebal… - Cellular and … - repositorioinstitucional.ceu.es
Antibodies and oxidative stress are hallmarks of multiple sclerosis (MS) lesions. We aimed
to clarify the relation between them, their role in MS patients and to investigate their …

Main role of antibodies in demyelination and axonal damage in multiple sclerosis

U Muñoz, C Sebal, E Escudero, M Esiri… - Cellular and Molecular …, 2022 - Springer
Antibodies and oxidative stress are hallmarks of multiple sclerosis (MS) lesions. We aimed
to clarify the relation between them, their role in MS patients and to investigate their …

Axonal and oligodendrocyte-localized IgM and IgG deposits in MS lesions

MC Sádaba, J Tzartos, C Paíno… - Journal of …, 2012 - Elsevier
BACKGROUND: Recent findings support the important role of antibodies in multiple
sclerosis (MS) physiopathology. Thus, local IgG synthesis is a hallmark of the disease, and …

Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis

E Herrero-Herranz, LA Pardo, R Gold, RA Linker - Neurobiology of disease, 2008 - Elsevier
Axonal damage is a correlate for increasing disability in multiple sclerosis. Animal models
such as experimental autoimmune encephalomyelitis (EAE) may help to develop better …

An update on multiple sclerosis

SL Hauser - Journal of the neurological sciences, 2005 - jns-journal.com
Multiple sclerosis (MS) is the prototypic inflammatory demyelinating disorder of the central
nervous system (CNS). MS is a clinically heterogeneous entity; symptoms may manifest in a …

Transient axonal injury in the absence of demyelination: a correlate of clinical disease in acute experimental autoimmune encephalomyelitis

F Aboul-Enein, P Weiser, R Höftberger… - Acta …, 2006 - Springer
Axonal degeneration contributes to the transient and permanent neurological deficits seen
in multiple sclerosis, an inflammatory disease of the central nervous system. To study the …

[HTML][HTML] Serum anti-oligodendrocyte autoantibodies in patients with multiple sclerosis detected by a tissue-based immunofluorescence assay

Y Miyachi, T Fujii, R Yamasaki, D Tsuchimoto… - Frontiers in …, 2021 - frontiersin.org
Multiple sclerosis (MS), the most prevalent inflammatory disease of the central nervous
system (CNS), is characterized by damaged to myelin sheaths and oligodendrocytes …

[HTML][HTML] Autoantibodies and neurodegeneration in multiple sclerosis

T Vyshkina, B Kalman - Laboratory investigation, 2008 - Elsevier
Neurodegeneration develops in association with inflammation and demyelination in multiple
sclerosis. Available data suggest that the progressive neuroaxonal loss begins in the …

Innate and adaptive immunity in amyotrophic lateral sclerosis: evidence of complement activation

M Sta, RMR Sylva-Steenland, M Casula… - Neurobiology of …, 2011 - Elsevier
Increasing evidence suggests a role for the immune system in amyotrophic lateral sclerosis
(ALS). To determine the extent of the immune activation in ALS we analyzed the expression …

Oxidative stress is differentially present in multiple sclerosis courses, early evident, and unrelated to treatment

M Gironi, B Borgiani, E Mariani… - Journal of …, 2014 - Wiley Online Library
Background. Oxidative stress is well documented in multiple sclerosis (MS) lesions, but its
correspondence at peripheral level is still controversial. Objective. To evaluate peripheral …