CD44, hyaluronan, the hematopoietic stem cell, and leukemia-initiating cells

M Zoeller - Frontiers in immunology, 2015 - frontiersin.org
CD44 is an adhesion molecule that varies in size due to glycosylation and insertion of so-
called variant exon products. The CD44 standard isoform (CD44s) is highly expressed in …

The biology of CD44 and HCELL in hematopoiesis: the 'step 2-bypass pathway'and other emerging perspectives

R Sackstein - Current opinion in hematology, 2011 - journals.lww.com
The biology of CD44 and HCELL in hematopoiesis: the ‘step 2-... : Current Opinion in
Hematology The biology of CD44 and HCELL in hematopoiesis: the ‘step 2-bypass pathway’ …

The biology and role of CD44 in cancer progression: therapeutic implications

C Chen, S Zhao, A Karnad, JW Freeman - Journal of hematology & …, 2018 - Springer
CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

CD44 integrates signaling in normal stem cell, cancer stem cell and (pre) metastatic niches

K Williams, K Motiani, PV Giridhar… - … biology and medicine, 2013 - journals.sagepub.com
The stem cell niche provides a regulatory microenvironment for cells as diverse as totipotent
embryonic stem cells to cancer stem cells (CSCs) which exhibit stem cell-like characteristics …

The importance of CD44 as a stem cell biomarker and therapeutic target in cancer

R Thapa, GD Wilson - Stem cells international, 2016 - Wiley Online Library
CD44 is a cell surface HA‐binding glycoprotein that is overexpressed to some extent by
almost all tumors of epithelial origin and plays an important role in tumor initiation and …

Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer

E Karousou, S Misra, S Ghatak, K Dobra, M Götte… - Matrix Biology, 2017 - Elsevier
Synthesis, deposition, and interactions of hyaluronan (HA) with its cellular receptor CD44
are crucial events that regulate the onset and progression of tumors. The intracellular …

Concise review: emerging role of CD44 in cancer stem cells: a promising biomarker and therapeutic target

Y Yan, X Zuo, D Wei - Stem cells translational medicine, 2015 - academic.oup.com
The reception and integration of the plethora of signals a cell receives from its
microenvironment determines the cell's fate. CD44 functions as a receptor for hyaluronan …

[HTML][HTML] The role of CD44 in fetal and adult hematopoietic stem cell regulation

H Cao, SY Heazlewood, B Williams, D Cardozo… - …, 2016 - ncbi.nlm.nih.gov
Throughout development, hematopoietic stem cells migrate to specific microenvironments,
where their fate is, in part, extrinsically controlled. CD44 standard as a member of the cell …

CD44 in hematological neoplasias

MK Hertweck, F Erdfelder, KA Kreuzer - Annals of hematology, 2011 - Springer
The CD44 protein family spans a large group of transmembrane glycoproteins acquired by
alternative splicing and post-translational modifications. The great heterogeneity in …

CD44 as a tumor biomarker and therapeutic target

H Xu, M Niu, X Yuan, K Wu, A Liu - Experimental hematology & oncology, 2020 - Springer
CD44, a complex transmembrane glycoprotein, exists in multiple molecular forms, including
the standard isoform CD44s and CD44 variant isoforms. CD44 participates in multiple …