Cations play key roles in regulating G-protein-coupled receptors (GPCRs), although their
mechanisms are poorly understood. Here, 19F NMR is used to delineate the effects of …

The function of G protein-coupled receptors (GPCRs) can be modulated by a number of
endogenous allosteric molecules. In this study, we used molecular dynamics, radioligand …

G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and
are important drug targets. Their diverse signaling pathways are driven by complex …

Signaling across cellular membranes, the 826 human G protein-coupled receptors (GPCRs)
govern a wide range of vital physiological processes, making GPCRs prominent drug …

Mutations that constitutively activate G protein-coupled receptors (GPCRs), known as
constitutively activating mutations (CAMs), modify cell signaling and interfere with drugs …

Understanding the roles of intermediate states in signaling is pivotal to unraveling the
activation processes of G protein-coupled receptors (GPCRs). However, the field is still …

The purine nucleoside adenosine is present in all cells in tightly regulated concentrations. It
is released under a variety of physiological and pathophysiological conditions to facilitate …

Pharmacological responses of G protein–coupled receptors (GPCRs) can be fine-tuned by
allosteric modulators. Structural studies of such effects have been limited due to the medium …

G protein-coupled receptors (GPCRs) are embedded in phospholipids that strongly
influence drug-stimulated signaling. Anionic lipids are particularly important for GPCR …

The adenosine A1 receptor is a member of the large membrane protein family that signals
through G proteins, the G protein-coupled receptors (GPCRs). GPCRs consist of seven …