Project A-Dual mechanism of regulation of G protein-gated potassium channels by δ-opioid
receptorsThe regulation of G protein-gated inwardly rectifying potassium channels (GIRK or …

The δ-and the κ-opioid receptors were individually co-expressed with the G-protein-
activated K+ (GIRK1) channel in Xenopus oocytes. Stimicrolation of these opioid receptors …

Many G protein-coupled receptor-mediated responses desensitize within minutes.
Sustained stimulation of μ-opioid receptors (MORs), which primarily signal through Gi/o …

Opioid receptors are coupled to a variety of effectors, including G protein-activated inwardly
rectifying potassium (GIRK) channels (also known as Kir3), adenylyl cyclases, and voltage …

The opioid, dopamine and serotonin receptors are crucial molecules in drug addictions.
Previous studies of signal transduction pathways from these receptors have shown that their …

This study assessed how conformational information encoded by ligand binding to δ-opioid
receptors (DORs) is transmitted to Kir3. 1/Kir3. 2 channels. Human embryonic kidney 293 …

To investigate the role of G-protein-activated inwardly rectifying K+ (GIRK) channels in
opioid-induced analgesia, we compared the effects of opioids in wild-type and weaver …

Background Although the efficacy of peripherally administered opioid has been
demonstrated in preclinical and clinical studies, the underlying mechanisms of its anti …

It is well known that activation of the cloned κ-opioid receptor by nanomolar concentrations
of U50488H (trans-(±)-3, 4-dichloro-N-methyl-N-(2-[1-pyrrolidinyl] cyclohexyl …

The effect of RGS4, a GTPase-activating protein, on the deactivation kinetics and basal
activity of GIRK1/GIRK2 channels activated by the human κ-opioid receptor (hKOR) was …