[HTML][HTML] Nanoassemblies designed for efficient nuclear targeting
M Skowicki, S Tarvirdipour, M Kraus… - Advanced Drug Delivery …, 2024 - Elsevier
One of the key aspects of coping efficiently with complex pathological conditions is
delivering the desired therapeutic compounds with precision in both space and time …
delivering the desired therapeutic compounds with precision in both space and time …
Nuclear drug delivery for cancer chemotherapy
M Sui, W Liu, Y Shen - Journal of controlled release, 2011 - Elsevier
Nanosystems with unique physical and biological properties have been extensively
explored for cancer targeted intracellular delivery of small-molecular chemotherapeutic …
explored for cancer targeted intracellular delivery of small-molecular chemotherapeutic …
Journey to the center of the cell: current nanocarrier design strategies targeting biopharmaceuticals to the cytoplasm and nucleus
EV Munsell, NL Ross… - Current pharmaceutical …, 2016 - ingentaconnect.com
New biopharmaceutical molecules, potentially able to provide more personalized and
effective treatments, are being identified through the advent of advanced synthetic biology …
effective treatments, are being identified through the advent of advanced synthetic biology …
A smart polymeric platform for multistage nucleus-targeted anticancer drug delivery
J Zhong, L Li, X Zhu, S Guan, Q Yang, Z Zhou, Z Zhang… - Biomaterials, 2015 - Elsevier
Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer
therapy, since the nucleus is one of the most frequent targets of drug action. Here we report …
therapy, since the nucleus is one of the most frequent targets of drug action. Here we report …
[HTML][HTML] Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials
Nucleus, as the machinery for genome transcription, play prominent roles to support the
fundamental cellular functions, the destruction of any of these specific parts would …
fundamental cellular functions, the destruction of any of these specific parts would …
Nuclear delivery of nanoparticle-based drug delivery systems by nuclear localization signals
Y Nie, G Fu, Y Leng - Cells, 2023 - mdpi.com
Nanomedicine 2.0 refers to the next generation of nanotechnology-based medical therapies
and diagnostic tools. This field focuses on the development of more sophisticated and …
and diagnostic tools. This field focuses on the development of more sophisticated and …
Overcoming the barriers of nuclear-targeted drug delivery using nanomedicine-based strategies for enhanced anticancer therapy
Targeted drug delivery is critical for improving the therapeutic benefits of anticancer drugs.
The active delivery strategy increases the bioavailability of drugs not only to the diseased …
The active delivery strategy increases the bioavailability of drugs not only to the diseased …
Intracellular delivery of nanocarriers for cancer therapy
YE Har-El, Y Kato - Current Nanoscience, 2007 - ingentaconnect.com
Drug delivery systems largely contribute to cancer therapy in terms of tumor targeting and
controlled release of cargo molecules. While targeting of tumor “tissue” has been achieved …
controlled release of cargo molecules. While targeting of tumor “tissue” has been achieved …
How successful is nuclear targeting by nanocarriers?
SN Tammam, HME Azzazy, A Lamprecht - Journal of Controlled Release, 2016 - Elsevier
The nucleus is ultimately the final target for many therapeutics treating various disorders
including cancers, heart dysfunction and brain disorders. Owing to their specialized cell …
including cancers, heart dysfunction and brain disorders. Owing to their specialized cell …
Multistage nanovehicle delivery system based on stepwise size reduction and charge reversal for programmed nuclear targeting of systemically administered …
L Li, W Sun, J Zhong, Q Yang, X Zhu… - Advanced Functional …, 2015 - Wiley Online Library
The nucleus is the final target of many first‐line chemotherapeutics, but the need to
overcome multiple physiological barriers imposes conflicting requirements for size and …
overcome multiple physiological barriers imposes conflicting requirements for size and …