This study attempted to develop and evaluate controlled-release matrix-type transdermal
patches with different ratios of hydrophilic polymers (sodium carboxymethylcellulose and …

Transdermal drug delivery systems (TDDSs) have become innovative, fascinating drug
delivery methods intended for skin application to achieve systemic effects. TDDSs overcome …

The present investigation was aimed to evaluate the possibility of using diŠerent
concentrations and polymeric grades of hydroxypropyl methylcellulose (K4M, K15M and …

Objective To achieve an effective topical formulation of Methotrexate (MTX) as a first-line
treatment of psoriasis, we formulated three MTX-loaded electrospun nanofibrous patches …

Methotrexate (MTX), a well known drug for the treatment of cancer and rheumatoid arthritis,
has gained prominence in the treatment of psoriasis over the period of years. However, the …

Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and
juvenile idiopathic arthritis (JIA) and it is mainly administered either orally or by …

Methotrexate (MTX) is one of the first-line treatments for moderate to severe psoriasis, while
the side effects caused by injection and oral administration of MTX greatly restrict its clinical …

Methotrexate (MTX) is an immunosuppressive drug for systemic use in the treatment of skin
diseases, however, MTX presents a number of side effects, such as hepatotoxicity. To …

Regarding the potential severe toxicity associated with systemic administration of
methotrexate (MTX), a topical formulation might be of greater utility for the treatment of …

Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and
disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity …