Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages
Y Guo, Y Liu, S Zhao, W Xu, Y Li, P Zhao… - Nature …, 2021 - nature.com
Oxidative stress contributes to the pathogenesis of acute lung injury. Protein S-
glutathionylation plays an important role in cellular antioxidant defense. Here we report that …
glutathionylation plays an important role in cellular antioxidant defense. Here we report that …
FABP5 deficiency impaired macrophage inflammation by regulating AMPK/NF-κB signaling pathway
Y Hou, D Wei, EA Bossila, Z Zhang, S Li… - The Journal of …, 2022 - journals.aai.org
Fatty acid binding protein 5 (FABP5) is mainly involved in the uptake, transport, and
metabolism of fatty acid in the cytoplasm, and its role in immune cells has been recognized …
metabolism of fatty acid in the cytoplasm, and its role in immune cells has been recognized …
FABP4/aP2 regulates macrophage redox signaling and inflammasome activation via control of UCP2
KA Steen, H Xu, DA Bernlohr - Molecular and cellular biology, 2017 - Am Soc Microbiol
Obesity-linked metabolic disease is mechanistically associated with the accumulation of
proinflammatory macrophages in adipose tissue, leading to increased reactive oxygen …
proinflammatory macrophages in adipose tissue, leading to increased reactive oxygen …
Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2
H Xu, AV Hertzel, KA Steen, Q Wang… - … and cellular biology, 2015 - Am Soc Microbiol
Chronic inflammation in obese adipose tissue is linked to endoplasmic reticulum (ER) stress
and systemic insulin resistance. Targeted deletion of the murine fatty acid binding protein …
and systemic insulin resistance. Targeted deletion of the murine fatty acid binding protein …
FABP4 activates the JAK2/STAT2 pathway via Rap1a in the homocysteine-induced macrophage inflammatory response in ApoE−/− mice atherosclerosis
L Xu, H Zhang, Y Wang, A Yang, X Dong, L Gu… - Laboratory …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory vascular disease, and inflammation plays a critical
role in its formation and progression. Elevated serum homocysteine (Hcy) is an independent …
role in its formation and progression. Elevated serum homocysteine (Hcy) is an independent …
Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial …
P Cole-Ezea, D Swan, D Shanley, J Hesketh - Free Radical Biology and …, 2012 - Elsevier
Intake of the micronutrient selenium, which is incorporated into 25 selenoproteins in
humans, has been implicated in affecting risk of colorectal cancer. A genetic variant in the …
humans, has been implicated in affecting risk of colorectal cancer. A genetic variant in the …
Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination
X Liu, H Cao, J Li, B Wang, P Zhang… - Cell Death & …, 2017 - nature.com
Lung ischemia-reperfusion (I/R) injury remains one of the most common complications after
various cardiopulmonary surgeries. The inflammation response triggered by the released …
various cardiopulmonary surgeries. The inflammation response triggered by the released …
Nrf2-regulated PPARγ expression is critical to protection against acute lung injury in mice
Rationale: The NF-E2 related factor 2 (Nrf2)–antioxidant response element (ARE) pathway
is essential for protection against oxidative injury and inflammation including hyperoxia …
is essential for protection against oxidative injury and inflammation including hyperoxia …
[HTML][HTML] FABP5 controls macrophage alternative activation and allergic asthma by selectively programming long-chain unsaturated fatty acid metabolism
Y Hou, D Wei, Z Zhang, H Guo, S Li, J Zhang, P Zhang… - Cell Reports, 2022 - cell.com
Fatty acids (FAs) are widely involved in diverse biological functions. In mice with myeloid-
specific deletion of fatty acid-binding protein 5 (FABP5), OVA-induced allergic airway …
specific deletion of fatty acid-binding protein 5 (FABP5), OVA-induced allergic airway …
[HTML][HTML] Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death
A Seiler, M Schneider, H Förster, S Roth, EK Wirth… - Cell metabolism, 2008 - cell.com
Oxidative stress in conjunction with glutathione depletion has been linked with various acute
and chronic degenerative disorders, yet the molecular mechanisms have remained unclear …
and chronic degenerative disorders, yet the molecular mechanisms have remained unclear …