A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its
clustered character that leads to the formation of complex lesions challenging the cellular …

DNA double-strand breaks (DSB) are considered to be critical primary lesions in the
formation of chromosomal aberrations. DSB may be induced by exogenous agents, such as …

Of the various types of DNA damage that can occur within the mammalian cell, the DNA
double strand break (DSB) is perhaps the most dangerous. DSBs are typically induced by …

DNA double-strand breaks (DSB) are considered the critical primary lesion in the formation
of chromosomal aberrations (CA). DSB occur spontaneously during the cell cycle and are …

It is widely accepted that unrepaired or misrepaired DNA double strand breaks (DSBs) lead
to the formation of chromosome aberrations. DSBs induced in the DNA of higher eukaryotes …

Double strand breaks (DSBs) are induced in the DNA following exposure of cells to ionizing
radiation (IR) and are highly consequential for genome integrity, requiring highly specialized …

DNA damage can occur as a result of endogenous metabolic reactions and replication
stress or from exogenous sources such as radiation therapy and chemotherapy. DNA …

Significance: Ionizing radiation (IR) can induce a wide range of unique deoxyribonucleic
acid (DNA) lesions due to the spatiotemporal correlation of the ionization produced. Of …

An incompletely defined alternative non-homologous end joining pathway (A-NHEJ)
frequently functioning as backup has recently been shown to process DNA double strand …

The faithful repair of DNA double-strand breaks (DSBs) is probably one of the most critical
tasks for a cell in order to maintain its genomic integrity since these lesions may lead to …