Gentiopicroside ameliorates bleomycin-induced pulmonary fibrosis in mice via inhibiting inflammatory and fibrotic process

C Chen, Y Wang, Y Wang, M Cheng, J Yin… - Biochemical and …, 2018 - Elsevier
Pulmonary fibrosis (PF) is a chronic and ultimately fatal interstitial lung disease of various
causes. The advent of nintedanib and pirfenidone provides treatment options for PF patients …

[HTML][HTML] Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats

L Gao, H Tang, H He, J Liu, J Mao, H Ji… - Frontiers in …, 2015 - frontiersin.org
Idiopathic pulmonary fibrosis is a progressive and lethal form of interstitial lung disease that
lacks effective therapies at present. Glycyrrhizic acid (GA), a natural compound extracted …

[HTML][HTML] Mefunidone ameliorates bleomycin-induced pulmonary fibrosis in mice

Y Han, M Jiang, R He, X Lv, X Liao, Y He… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial
lung diseases with poor prognosis. Currently, few effective drugs are available for IPF …

[HTML][HTML] Hyperoside attenuates bleomycin-induced pulmonary fibrosis development in mice

J Huang, X Tong, L Zhang, Y Zhang, L Wang… - Frontiers in …, 2020 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal, and chronic lung disease. There
are no effective drug therapies for IPF. Hyperoside, a flavonoid glycoside, has been proven …

Ganoderic acid A inhibits bleomycin-induced lung fibrosis in mice

G Wen, T Li, H He, X Zhou, J Zhu - Pharmacology, 2020 - karger.com
Background: To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-
induced pulmonary fibrosis. Methods: ICR mice were intratracheally instilled with BLM to …

Osthole alleviates bleomycin-induced pulmonary fibrosis via modulating angiotensin-converting enzyme 2/angiotensin-(1–7) axis and decreasing inflammation …

Y Hao, Y Liu - Biological and Pharmaceutical Bulletin, 2016 - jstage.jst.go.jp
Studies have shown that angiotensin-converting enzyme 2 (ACE2) plays modulating roles in
lung pathophysiology, including pulmonary fibrosis (PF) and acute lung injury. Pulmonary …

[HTML][HTML] Azithromycin attenuates bleomycin-induced pulmonary fibrosis partly by inhibiting the expression of LOX and LOXL-2

X Tong, S Zhang, D Wang, L Zhang, J Huang… - Frontiers in …, 2021 - frontiersin.org
Pulmonary fibrosis (PF) is a chronic and progressive process of tissue repair. Azithromycin
(AZM) may be beneficial for the treatment of PF because AZM has anti-inflammatory and …

Fucoxanthin inhibits profibrotic protein expression in vitro and attenuates bleomycin-induced lung fibrosis in vivo

SY Ma, WS Park, DS Lee, G Choi, MJ Yim… - European journal of …, 2017 - Elsevier
Pulmonary fibrosis, a potentially fatal disease, results from acute and chronic interstitial lung
diseases. Fucoxanthin (Fx), a carotenoid found in brown seaweed, shows a wide range of …

[HTML][HTML] Hesperidin ameliorates bleomycin-induced experimental pulmonary fibrosis via inhibition of TGF-beta1/Smad3/AMPK and IkappaBalpha/NF-kappaB …

Z Zhou, AD Kandhare, AA Kandhare… - EXCLI …, 2019 - ncbi.nlm.nih.gov
Bleomycin (BLM) is a chemotherapeutic agent which is associated with Idiopathic
pulmonary fibrosis (IPF) due to its chronic administration. Hesperidin, a bioflavonoid has …

Cryptotanshinone reverses the epithelial‐mesenchymal transformation process and attenuates bleomycin‐induced pulmonary fibrosis

Q Zhang, C Gan, H Liu, L Wang, Y Li… - Phytotherapy …, 2020 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fibrotic interstitial pneumonia that causes pulmonary
tissue damage and functional impairment. To investigate the effects of cryptotanshinone on …