Age-associated B cells
MP Cancro - Annual review of immunology, 2020 - annualreviews.org
The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …
decade. These cells have a unique cell surface phenotype and transcriptional signature …
Age‐associated B cells: key mediators of both protective and autoreactive humoral responses
A subset of B cells with unique phenotypic and functional features—termed Age‐associated
B cells (ABCs)—has recently been identified in both mice and humans. These cells are …
B cells (ABCs)—has recently been identified in both mice and humans. These cells are …
B cell dysfunction associated with aging and autoimmune diseases
S Ma, C Wang, X Mao, Y Hao - Frontiers in immunology, 2019 - frontiersin.org
Impaired humoral responses, as well as an increased propensity for autoimmunity, play an
important role in the development of immune system dysfunction associated with aging …
important role in the development of immune system dysfunction associated with aging …
Molecular mechanisms controlling age‐associated B cells in autoimmunity
S Phalke, J Rivera‐Correa, D Jenkins… - Immunological …, 2022 - Wiley Online Library
Age‐associated B cells (ABCs) have emerged as critical components of immune responses.
Their inappropriate expansion and differentiation have increasingly been linked to the …
Their inappropriate expansion and differentiation have increasingly been linked to the …
B cells and aging: molecules and mechanisms
Recent advances allow aging-associated changes in B-cell function to be approached at a
mechanistic level. Reduced expression of genes crucial to lineage commitment and …
mechanistic level. Reduced expression of genes crucial to lineage commitment and …
Lymphocyte generation and population homeostasis throughout life
RE Yanes, CE Gustafson, CM Weyand… - Seminars in …, 2017 - Elsevier
Immune aging is a multi-faceted process that manifests as reduced competence to fight
infections and malignant cells, as well as diminished tissue repair, unprovoked …
infections and malignant cells, as well as diminished tissue repair, unprovoked …
The dynamics of B cell aging in health and disease
J de Mol, J Kuiper, D Tsiantoulas, AC Foks - Frontiers in Immunology, 2021 - frontiersin.org
Aging is considered to be an important risk factor for several inflammatory diseases. B cells
play a major role in chronic inflammatory diseases by antibody secretion, antigen …
play a major role in chronic inflammatory diseases by antibody secretion, antigen …
Immune aging–A mechanism in autoimmune disease
Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …
autoimmunity. Over lifetime, the immune system adapts to profound changes in …
B cell maintenance and function in aging
In this review we discuss the changes that occur in the B lymphocyte compartment of mice
and humans as they progress to old age, focusing on recent advances in this important area …
and humans as they progress to old age, focusing on recent advances in this important area …
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice
Age-associated B cells (ABCs) are formed under inflammatory conditions and are
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …